AKAP7
AKAP7 (A-kinase anchoring protein 7, also known as AKAP18 and AKAP15) is a member of the AKAP family that tethers cAMP-dependent protein kinase (PKA) to the plasma membrane. It couples PKA to the L-type calcium channel and influences epithelial sodium channel activity. Browse Assay Genie's current range of AKAP7 research reagents below, or read on for the biology behind the target.
AKAP7 targets cAMP-dependent protein kinase (PKA) to the plasma membrane and permits functional coupling of the kinase to the L-type calcium channel. It also affects sodium handling: the membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. By positioning PKA close to its targets, AKAP7 helps confine cAMP signalling to defined cellular locations.
The AKAP7 gene encodes a member of the A-kinase anchoring protein family. These proteins bind the regulatory subunit (RII) of PKA and direct the enzyme to specific subcellular compartments. All AKAPs share a common RII-binding domain but carry different targeting motifs, which send PKA to distinct intracellular sites. In UniProt, AKAP7 is annotated at the lateral and apical cell membrane. The UniProt entry is named A-kinase anchor protein 7 isoforms alpha and beta, and RefSeq describes three alternatively spliced transcript variants encoding different isoforms.
AKAP7 is also known as AKAP18 and, under a previous symbol, AKAP15; its earlier name was A kinase (PRKA) anchor protein 7. HGNC places it in the A-kinase anchoring proteins gene group. Orthologous Akap7 genes are listed in mouse and rat, so the target can be studied in common model systems. Researchers working on AKAP7 often look at PKA localisation, calcium channel regulation and ion transport.
AKAP7 anchors PKA through its RII-binding domain, making it a useful target for studying how cAMP signalling is compartmentalised.
AKAP7 permits functional coupling of PKA to the L-type calcium channel at the plasma membrane.
Membrane-associated AKAP7 reduces ENaC activity, while the free cytoplasmic form may affect feedback inhibition by intracellular sodium.
Three alternatively spliced transcript variants encode different AKAP7 isoforms, supporting work on isoform-specific localisation and function.
AKAP7 targets cAMP-dependent protein kinase (PKA) to the plasma membrane and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, while the free cytoplasmic form may negatively regulate ENaC feedback inhibition by intracellular sodium.
AKAP7 is also called AKAP18, and AKAP15 is a previous symbol. Its earlier name was A kinase (PRKA) anchor protein 7. The UniProt entry covers isoforms alpha and beta, and RefSeq describes three alternatively spliced transcript variants encoding different isoforms.
Yes. Orthologous Akap7 genes are recorded for both mouse and rat, which allows the protein's function to be studied in rodent models. Check the datasheet of any product for its validated reactivity.
Other A-kinase anchoring proteins that target PKA to specific subcellular compartments.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43687; product specifications from Assay Genie datasheets.