PNMA2
PNMA2 (PNMA family member 2) is a member of the paraneoplastic Ma antigen group, also known as paraneoplastic antigen Ma2, MA2 and RGAG2. It is predicted to be located in the nucleolus and to be involved in positive regulation of apoptosis. Browse Assay Genie's current range of PNMA2 research reagents below, or read on for the biology behind the target.
PNMA2 is the protein product of the PNMA2 gene and belongs to the PNMA family. Current annotation of its function is limited and based on prediction. The NCBI Gene summary, provided by the Alliance of Genome Resources, describes PNMA2 as predicted to be involved in positive regulation of the apoptotic process. It is also predicted to be located in the nucleolus, which matches the nucleolar subcellular location recorded in UniProt.
The human PNMA2 gene is catalogued by HGNC as PNMA family member 2 and sits within the gene group of paraneoplastic Ma antigens. UniProt lists the protein as paraneoplastic antigen Ma2. Researchers working on the PNMA2 gene or PNMA2 protein will find the mouse ortholog named Pnma2. No detailed UniProt function annotation is currently available, so mechanistic claims should be treated with care and checked against primary literature.
The name reflects the history of the family. Earlier names include paraneoplastic antigen MA2 and paraneoplastic Ma antigen 2, and the aliases MA2 and RGAG2 are still found in older papers and databases. Searching under all of these names helps when reviewing earlier work on this target. The family designation, PNMA, ties it to other Ma antigens that are grouped together on the basis of shared sequence relationships.
PNMA2 is predicted to take part in positive regulation of the apoptotic process, making it a candidate for studies of cell death regulation.
The predicted nucleolar location of PNMA2 makes it relevant to studies of nucleolar proteins and their roles within the nucleus.
PNMA2 belongs to the paraneoplastic Ma antigens gene group, so it is relevant to work on this antigen family.
As a PNMA family member, PNMA2 can be compared with related family genes and with the mouse ortholog Pnma2.
The function of PNMA2 is not fully characterised. The NCBI Gene summary says it is predicted to be involved in positive regulation of the apoptotic process and predicted to be located in the nucleolus. UniProt records a nucleolar location but gives no detailed function annotation.
PNMA2 stands for PNMA family member 2. UniProt calls it paraneoplastic antigen Ma2, and aliases include MA2 and RGAG2. Previous names are paraneoplastic antigen MA2 and paraneoplastic Ma antigen 2. These names may all appear in the literature.
A mouse ortholog, Pnma2, is recorded for the human gene. PNMA2 also belongs to the PNMA family and the HGNC group of paraneoplastic Ma antigens. Check the datasheet of any product for its validated reactivity.
Other PNMA family members and paraneoplastic Ma antigens with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UL42; product specifications from Assay Genie datasheets.