FOSL2
FOSL2 (FOS like 2, AP-1 transcription factor subunit), also known as FRA2 or Fos-related antigen 2, is a nuclear bZIP transcription factor of the Fos subfamily. It dimerises with JUN proteins to form AP-1 and controls osteoclast survival and size. Browse Assay Genie's current range of FOSL2 research reagents below, or read on for the biology behind the target.
FOSL2 is a transcription factor that acts as a subunit of the AP-1 complex. As a dimer with JUN, it activates transcription of LIF. It also activates CEBPB transcription in osteoblasts activated by PGE2. At the cellular level, the protein controls osteoclast survival and size, linking AP-1 activity to bone cell biology.
The FOSL2 protein belongs to the bZIP family and the Fos subfamily, and it is found in the nucleus. The Fos gene family has four members: FOS, FOSB, FOSL1 and FOSL2. These genes encode leucine zipper proteins that dimerise with proteins of the JUN family, forming the AP-1 transcription factor complex. The FOSL2 gene is placed in the HGNC Fos transcription factor family, and mouse and rat each have an ortholog named Fosl2, which makes rodent models a practical route for functional work.
As members of the Fos family, FOS proteins have been implicated as regulators of cell proliferation, differentiation and transformation. The gene was previously named FOS like antigen 2, and the symbols FRA2 and FLJ23306 appear in older literature. Researchers studying the FOSL2 gene or protein often compare it with its paralogue FOSL1 to separate the roles of individual Fos subunits within AP-1.
FOSL2 dimerises with JUN proteins to form AP-1, making it a subunit of interest when dissecting Fos and JUN contributions to gene regulation.
FOSL2 controls osteoclast survival and size, so it is studied in osteoclast function and in the regulation of bone cells.
In PGE2-activated osteoblasts, FOSL2 activates CEBPB transcription, offering a route to examine prostaglandin-driven transcriptional responses.
Fos family proteins are implicated in regulating cell proliferation, differentiation and transformation, placing FOSL2 in studies of these processes.
FOSL2 is a nuclear transcription factor that forms AP-1 as a dimer with JUN proteins. It controls osteoclast survival and size, activates LIF transcription with JUN, and activates CEBPB transcription in PGE2-activated osteoblasts.
FOSL2 is also called FRA2 and Fos-related antigen 2. FLJ23306 is a previous symbol, and the earlier gene name was FOS like antigen 2. The current HGNC name is FOS like 2, AP-1 transcription factor subunit.
FOSL2 belongs to the bZIP family, Fos subfamily, alongside FOS, FOSB and FOSL1. Mouse and rat both have a Fosl2 ortholog. Check the datasheet of any product for its validated reactivity.
Other Fos family members, JUN partners and downstream targets of AP-1 signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P15408; product specifications from Assay Genie datasheets.