NCOA1
NCOA1 (nuclear receptor coactivator 1, also known as SRC1, NCoA-1, KAT13A, RIP160 and bHLHe74) is a nuclear transcriptional coactivator. It binds nuclear receptors directly and stimulates their transcriptional activity in a hormone-dependent fashion. Browse Assay Genie's current range of NCOA1 research reagents below, or read on for the biology behind the target.
NCOA1 is a nuclear receptor coactivator that binds nuclear receptors directly and stimulates their transcriptional activity in a hormone-dependent manner. It is involved in coactivation of steroid receptors (PGR, GR and ER), retinoid receptors (RXRs), thyroid hormone receptors (TRs) and prostanoid receptors (PPARs). It also contributes to coactivation mediated by the transcription factors STAT3, STAT5A, STAT5B and STAT6, and is required for mediating the steroid hormone response.
The protein plays a central role in building multisubunit coactivator complexes that act through chromatin remodelling. It may also act by taking part in both chromatin remodelling and recruitment of general transcription factors. NCOA1 shows histone acetyltransferase activity toward histones H3 and H4, although the relevance of this activity remains unclear. Together with NCOA2, it is required to control energy balance between white and brown adipose tissues.
The NCOA1 gene encodes a member of the SRC/p160 nuclear receptor coactivator family. The protein contains a nuclear localisation signal along with bHLH and PAS domains, and HGNC classifies it among basic helix-loop-helix proteins, lysine acetyltransferases and PAS domain containing proteins. Alternatively spliced transcript variants encode different isoforms; isoform 2 has higher thyroid hormone-dependent transactivation activity than isoforms 1 and 3. The mouse ortholog is Ncoa1. Related family members include NCOA3 and NCOA4 pages listed below.
NCOA1 directly binds nuclear receptors and drives hormone-dependent transcription, making it a core component for studying steroid, retinoid, thyroid hormone and prostanoid receptor signalling.
NCOA1 helps assemble multisubunit coactivator complexes that act through chromatin remodelling and may recruit general transcription factors.
NCOA1 is required for mediating steroid hormone response and coactivates PGR, GR and ER.
With NCOA2, NCOA1 is required to control energy balance between white and brown adipose tissues.
NCOA1 is a nuclear receptor coactivator that binds receptors directly and stimulates hormone-dependent transcription. It helps form coactivator complexes that remodel chromatin and may recruit general transcription factors. It also shows histone acetyltransferase activity toward H3 and H4, though the relevance of this remains unclear.
NCOA1 is also called SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160 and bHLHe74. Alternatively spliced transcript variants encode different isoforms. Isoform 2 has higher thyroid hormone-dependent transactivation activity than isoforms 1 and 3.
NCOA1 belongs to the SRC/p160 nuclear receptor coactivator family, which includes NCOA2 and NCOA3. A mouse ortholog, Ncoa1, exists; check the datasheet of any product for its validated reactivity.
Other nuclear receptor coactivators from the NCOA group with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15788; product specifications from Assay Genie datasheets.