GADD45G
GADD45G (growth arrest and DNA damage inducible gamma, also known as DDIT2, GADD45gamma, GRP17 and CR6) is a member of the GADD45 family of stress-inducible proteins. It helps regulate growth and apoptosis and mediates activation of the p38/JNK pathway. Browse Assay Genie's current range of GADD45G research reagents below, or read on for the biology behind the target.
GADD45G is involved in the regulation of growth and apoptosis. It responds to environmental stress by mediating activation of the p38/JNK pathway through the stress-responsive MAPKKK MTK1/MEKK4. This places the GADD45G protein between cellular stress signals and the downstream MAP kinase cascades that determine whether a cell arrests, repairs or undergoes apoptosis.
The GADD45G gene belongs to a group of genes whose transcript levels rise after stressful growth arrest conditions and after treatment with DNA-damaging agents. It is a member of the GADD45 family, which in the HGNC classification is the growth arrest and DNA damage inducible family. Human GADD45G is highly expressed in placenta, according to the NCBI Gene summary. Mouse and rat orthologs are both named Gadd45g.
The gene has also been listed as DDIT2, GADD45gamma, GRP17 and CR6, and its earlier HGNC name was growth arrest and DNA-damage-inducible, gamma. Because it is transcriptionally induced by stress, GADD45G is often studied alongside other family members such as GADD45A, and researchers measure it as a readout of DNA damage and stress-response signalling.
GADD45G mediates activation of the p38/JNK pathway via MTK1/MEKK4, making it a useful node for studying how cells respond to environmental stress.
Transcript levels of GADD45G increase after treatment with DNA-damaging agents, so it serves as a marker of genotoxic stress responses.
GADD45G is involved in regulating growth and apoptosis, relevant to studies of cell-cycle arrest and cell fate decisions.
High expression of GADD45G in placenta makes it a point of interest for studies of placental gene expression.
GADD45G is involved in the regulation of growth and apoptosis. In response to environmental stress it mediates activation of the p38/JNK pathway through the MAPKKK MTK1/MEKK4. Its transcript levels increase after growth arrest conditions and exposure to DNA-damaging agents.
GADD45G is the HGNC symbol for growth arrest and DNA damage inducible gamma. Aliases and previous symbols include DDIT2, GADD45gamma, GRP17 and CR6. The UniProt entry is named Growth arrest and DNA damage-inducible protein GADD45 gamma.
Orthologs of GADD45G exist in mouse and rat, where the gene is named Gadd45g. It belongs to the GADD45 family, which also includes GADD45A. Check the datasheet of any product for its validated reactivity.
Other GADD45 family members and related stress-response targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95257; product specifications from Assay Genie datasheets.