THBS3
THBS3 (thrombospondin 3) is an adhesive glycoprotein of the thrombospondin family that mediates cell-to-cell and cell-to-matrix interactions. It assembles as a pentameric molecule and binds several extracellular matrix proteins, including fibronectin, laminin and type V collagen. Browse Assay Genie's current range of THBS3 research reagents below, or read on for the biology behind the target.
THBS3 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This role is shared by the members of the thrombospondin family, to which it belongs. According to UniProt, thrombospondin-3 can bind to fibrinogen, fibronectin, laminin and type V collagen, which places it among the proteins that link cells to the surrounding extracellular matrix.
The THBS3 protein forms a pentameric molecule linked by a single disulfide bond. The human THBS3 gene is located at 1q22 and encodes a protein of 956 amino acids. NCBI Gene notes that the gene shares a common promoter with metaxin 1, and that alternate splicing produces both coding and non-coding transcript variants. A mouse ortholog, Thbs3, is recorded for the gene. Subcellular location is not annotated in UniProt, and no tissue expression data are included here.
THBS3 is classified by HGNC in the thrombospondin family, alongside related members such as THBS2 and THBS4. Researchers studying cell adhesion, matrix organisation and thrombospondin biology can use THBS3 as a defined point of comparison within this family. Because the sources summarised here describe function and structure rather than disease association, any disease link should be checked against primary literature before it is assumed.
THBS3 is an adhesive glycoprotein that mediates cell-to-cell interactions, making it relevant to work on how cells attach to one another.
THBS3 mediates cell-to-matrix interactions and binds fibronectin, laminin and type V collagen, so it is relevant to matrix composition and organisation.
As a member of the thrombospondin family, THBS3 supports comparative work across family members that share adhesive glycoprotein functions.
THBS3 forms a pentameric molecule linked by a single disulfide bond, which makes it of interest for studies of oligomeric extracellular proteins.
THBS3 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. UniProt reports that it can bind fibrinogen, fibronectin, laminin and type V collagen. The protein assembles into a pentamer linked by a single disulfide bond.
THBS3 is the HGNC symbol for thrombospondin 3, and UniProt names the protein thrombospondin-3. No alternative aliases or previous symbols are listed. NCBI Gene reports that alternate splicing gives coding and non-coding transcript variants, and that the gene shares a promoter with metaxin 1.
A mouse ortholog, Thbs3, is recorded for the human THBS3 gene. THBS3 also belongs to the wider thrombospondin family, which includes THBS2 and THBS4. Check the datasheet of any product for its validated reactivity.
Other thrombospondin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49746; product specifications from Assay Genie datasheets.