HMGB4
HMGB4 (high mobility group box 4, also known as FLJ40388) is a nuclear protein of the HMGB family and a member of the canonical high mobility group. It is predicted to bind DNA and to take part in chromatin remodelling. Browse Assay Genie's current range of HMGB4 research reagents below, or read on for the biology behind the target.
HMGB4 is a member of the HMGB family of high mobility group proteins. Based on the available gene annotation, the protein is predicted to enable DNA binding activity and to be involved in chromatin remodelling. These are predicted functions rather than experimentally detailed mechanisms, so HMGB4 is best approached as a chromatin-associated protein whose precise roles are still being defined.
The HMGB4 protein is located in the nucleus and is associated with chromosomes. The human gene is classified by HGNC within the canonical high mobility group, alongside the other HMGB proteins. A mouse ortholog, Hmgb4, is recorded, which allows comparative work between human and mouse systems. Researchers studying this target often consider it together with its better-characterised relatives HMGB1, HMGB2 and HMGB3.
The gene has appeared in the literature under the previous symbol FLJ40388, and its earlier name was written as high-mobility group box 4. Both are useful search terms when reviewing older records. Because the functional annotation is currently limited to prediction, any HMGB4 antibody, HMGB4 ELISA kit or HMGB4 protein reagent is mainly of interest for characterising its expression, localisation and role in chromatin biology.
HMGB4 is predicted to be involved in chromatin remodelling, making it a candidate for studies of chromatin organisation and regulation.
HMGB4 is predicted to enable DNA binding activity, so it is relevant to work on how HMGB family proteins interact with DNA.
HMGB4 is located in the nucleus and associated with chromosomes, supporting investigation of its distribution in the nucleus.
As an HMGB family member, HMGB4 is useful for comparing its properties with HMGB1, HMGB2 and HMGB3.
HMGB4 is predicted to enable DNA binding activity and to be involved in chromatin remodelling. It is located in the nucleus and associated with chromosomes. These functions are predicted from gene annotation, and its detailed molecular role remains to be fully described.
HMGB4 stands for high mobility group box 4, previously written as high-mobility group box 4. The older symbol FLJ40388 is also recorded as an alias, and UniProt lists the protein as high mobility group protein B4.
A mouse ortholog, Hmgb4, is recorded for the human gene. HMGB4 belongs to the HMGB family, which also includes HMGB1, HMGB2 and HMGB3. Check the datasheet of any product for its validated reactivity.
Other HMGB family proteins and chromatin-associated nuclear targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WW32; product specifications from Assay Genie datasheets.