AK1
AK1 (adenylate kinase 1, also known as ADK or Adk1) is a cytoplasmic phosphotransferase that catalyses the reversible transfer of the terminal phosphate between ATP and AMP. It supports cellular energy homeostasis and adenine nucleotide metabolism. Browse Assay Genie's current range of AK1 research reagents below, or read on for the biology behind the target.
AK1 catalyses the reversible transfer of the terminal phosphate group between ATP and AMP, a reaction that helps keep cellular adenine nucleotide pools in balance. The enzyme also shows broad nucleoside diphosphate kinase activity and plays an important role in cellular energy homeostasis and adenine nucleotide metabolism. At a very low rate it also catalyses the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP.
The AK1 gene encodes adenylate kinase isoenzyme 1, which belongs to the adenylate kinase family and the AK1 subfamily. The protein is found in the cytoplasm. According to the NCBI Gene summary, the gene is highly expressed in skeletal muscle, brain and erythrocytes, and it is involved in the homeostasis of adenine nucleotide ratios in different intracellular compartments. Alternative splicing produces multiple transcript variants encoding different isoforms. Mouse and rat both carry an orthologous Ak1 gene.
HGNC places AK1 in the adenylate kinases gene group and also lists it among the microRNA protein coding host genes. The gene shares readthrough transcripts with the upstream ST6GALNAC6 gene. Certain mutations that result in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic haemolytic anaemia, which makes AK1 a useful reference point for studying red cell energy metabolism.
AK1 interconverts adenine nucleotides and contributes to cellular energy homeostasis, making it a focus for studies of ATP, ADP and AMP balance.
Alongside its ATP:AMP activity, AK1 shows broad nucleoside diphosphate kinase activity, relevant to adenine nucleotide metabolism research.
Mutations that leave AK1 functionally inadequate are associated with nonspherocytic haemolytic anaemia, linking the enzyme to red cell disorders.
High expression in skeletal muscle, brain and erythrocytes makes AK1 relevant to energy metabolism in these tissues.
AK1 catalyses the reversible transfer of the terminal phosphate group between ATP and AMP and also shows broad nucleoside diphosphate kinase activity. It contributes to cellular energy homeostasis and adenine nucleotide metabolism, and catalyses thiamine triphosphate synthesis from ThDP and ADP at a very low rate.
HGNC names the gene adenylate kinase 1, and UniProt names the protein adenylate kinase isoenzyme 1. Aliases include ADK and Adk1. Alternative splicing gives multiple transcript variants that encode different isoforms, and AK1 also shares readthrough transcripts with the upstream ST6GALNAC6 gene.
Mouse and rat each have an orthologous Ak1 gene; check the datasheet of any product for its validated reactivity. Certain AK1 mutations that produce a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic haemolytic anaemia.
Other adenylate kinases and similarly named kinase and reductase targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P00568; product specifications from Assay Genie datasheets.