ECRG4
ECRG4 (ECRG4 augurin precursor), also known as augurin and formerly C2orf40, is a probable hormone of the augurin family. It may attenuate cell proliferation and induce senescence in oligodendrocyte and neural precursor cells of the central nervous system. Browse Assay Genie's current range of ECRG4 research reagents below, or read on for the biology behind the target.
ECRG4 is described as a probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterised by G1 arrest, dephosphorylation of RB1 and accelerated proteasomal degradation of the cyclins CCND1 and CCND3. These features link the protein to control of cell-cycle progression in neural precursor populations.
The ECRG4 gene encodes augurin, the product named in UniProt, and the protein belongs to the augurin family. Annotation places it in several compartments: it is secreted, found in the cytoplasm, and located at the apical cell membrane. Gene Ontology-based annotation from NCBI Gene also records localisation to the apical plasma membrane and dense core granules, consistent with a role as a secreted peptide.
NCBI Gene summarises the molecular function of ECRG4 as neuropeptide hormone activity. It is involved in the neuropeptide signalling pathway, positive regulation of hormone secretion and vasopressin secretion. The gene was previously designated chromosome 2 open reading frame 40 (C2orf40), and orthologues are present in mouse and rat, both named Ecrg4. Researchers studying the ECRG4 gene or augurin protein often focus on senescence, cell-cycle control and neuroendocrine signalling.
ECRG4 is linked to induction of senescence in oligodendrocyte and neural precursor cells, making it relevant to studies of senescence mechanisms.
ECRG4-induced G1 arrest involves RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation, offering a model for cyclin control.
Annotated with neuropeptide hormone activity and a role in the neuropeptide signalling pathway, ECRG4 is relevant to peptide hormone biology.
ECRG4 is involved in positive regulation of hormone secretion and vasopressin secretion, and is found in dense core granules.
ECRG4 is a probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. Senescence involves G1 arrest, RB1 dephosphorylation and faster proteasomal degradation of CCND1 and CCND3. NCBI Gene also lists neuropeptide hormone activity.
ECRG4 is the HGNC symbol for ECRG4 augurin precursor. The protein is called augurin in UniProt, and the earlier gene symbol was C2orf40, from the former name chromosome 2 open reading frame 40. It belongs to the augurin family.
Yes. Mouse and rat both have an orthologue named Ecrg4, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Cell-cycle regulators, cyclins and neuropeptide hormones connected to ECRG4 biology, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H1Z8; product specifications from Assay Genie datasheets.