FABP7
FABP7 (fatty acid binding protein 7), also known as B-FABP and BLBP, is a small cytoplasmic member of the fatty acid-binding protein family. It binds long-chain fatty acids and other hydrophobic ligands and is important for radial glial fibre formation in the developing brain. Browse Assay Genie's current range of FABP7 research reagents below, or read on for the biology behind the target.
FABP7 is a small, highly conserved cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands. UniProt notes that it could be involved in transporting a so far unknown hydrophobic ligand with potential morphogenic activity during central nervous system (CNS) development. It is required for the establishment of the radial glial fibre system in developing brain, a scaffold that immature neurons need in order to migrate and establish the cortical layers.
The FABP7 gene encodes brain fatty acid-binding protein, which belongs to the calycin superfamily and to the fatty acid-binding protein (FABP) family. According to NCBI Gene, alternative splicing and promoter usage give rise to multiple transcript variants that encode different isoforms, and pseudogenes of the gene are found on several chromosomes. Mouse and rat both have an orthologous Fabp7 gene, which allows the protein to be studied in common rodent models of brain development.
The protein is known as B-FABP and BLBP, and the gene was previously named fatty acid binding protein 7, brain. These names reflect its link to the brain and to radial glia. Researchers working with an FABP7 antibody, an FABP7 ELISA kit or recombinant FABP7 protein typically do so to examine lipid-binding proteins in neural development. Other FABP family members, including FABP1, FABP4, FABP5 and FABP6, share the same fold but are studied in other contexts.
FABP7 is required for establishing the radial glial fibre system in developing brain, making it a key protein for studying CNS development.
Radial glial fibres guide immature neurons during migration to establish cortical layers, a process that depends on FABP7.
FABP7 binds long-chain fatty acids and other hydrophobic ligands, so it is relevant to studies of intracellular hydrophobic ligand transport.
As a calycin superfamily member within the FABP family, FABP7 is a useful reference point when comparing family members and their roles.
FABP7 is a cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands. It may transport a hydrophobic ligand with potential morphogenic activity during CNS development, and it is required for the radial glial fibre system that supports neuronal migration in developing brain.
FABP7 is also called B-FABP and BLBP, and its UniProt name is fatty acid-binding protein, brain. The gene was previously named fatty acid binding protein 7, brain. NCBI Gene reports that alternative splicing and promoter usage produce multiple transcript variants encoding different isoforms.
NCBI Gene describes the encoded protein as highly conserved. Mouse and rat each have an orthologous gene named Fabp7. For work in a particular species, check the datasheet of any product for its validated reactivity.
Other members of the fatty acid-binding protein family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15540; product specifications from Assay Genie datasheets.