GMFB
GMFB (glia maturation factor beta, also known as GMF) is a member of the actin-binding ADF family, GMF subfamily. UniProt annotates it as a protein that promotes differentiation of brain cells and neural regeneration while inhibiting tumour cell proliferation. Browse Assay Genie's current range of GMFB research reagents below, or read on for the biology behind the target.
According to UniProt, the GMFB protein causes differentiation of brain cells, stimulates neural regeneration and inhibits the proliferation of tumour cells. These activities gave the protein its name, glia maturation factor beta, and make it a subject of interest in neurobiology and cancer research.
At the molecular level, GMFB belongs to the actin-binding proteins ADF family and the GMF subfamily. The NCBI Gene summary, based on predictions from the Alliance of Genome Resources, indicates that it enables Arp2/3 complex binding. It is also predicted to take part in actin filament debranching and in the negative regulation of Arp2/3 complex-mediated actin nucleation. In this model, GMFB helps to control how branched actin networks are built and disassembled. It is predicted to be active in the cortical actin cytoskeleton.
The same summary predicts that the GMFB gene acts upstream of or within learning and locomotory behaviour. These assignments are predictions rather than established findings, so the precise physiological roles of GMFB still need experimental confirmation. HGNC classifies the gene in the glia maturation factor family and lists GMF as an alias. Orthologous genes, both named Gmfb, are found in mouse and rat, which allows the protein to be studied in rodent models. Researchers studying GMFB typically use a GMFB antibody or GMFB ELISA kit to examine expression and abundance in neural and other biological contexts.
GMFB is annotated as causing differentiation of brain cells, making it relevant to studies of glial and neuronal maturation.
UniProt reports that GMFB stimulates neural regeneration, which makes it a candidate for work on nervous system repair.
As an ADF-family protein predicted to bind the Arp2/3 complex, GMFB is relevant to actin debranching and nucleation research.
GMFB is annotated as inhibiting the proliferation of tumour cells, which makes it of interest in cancer cell biology.
UniProt describes GMFB as a protein that causes differentiation of brain cells, stimulates neural regeneration and inhibits tumour cell proliferation. NCBI Gene also predicts a role in actin filament debranching and in negative regulation of Arp2/3 complex-mediated actin nucleation.
GMFB stands for glia maturation factor beta, and GMF is listed as an alias. HGNC places it in the glia maturation factor family, and UniProt assigns it to the actin-binding proteins ADF family, GMF subfamily.
Yes. Mouse and rat each have an ortholog named Gmfb, so the protein can be studied in rodent systems. Check the datasheet of any product for its validated reactivity.
Other glia maturation factor family members, Arp2/3 complex components and actin-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P60983; product specifications from Assay Genie datasheets.