FLOT2
FLOT2 (flotillin 2) is a caveolae-associated integral membrane protein of the flotillin subfamily, thought to act as a scaffold within caveolar membranes. It is also known as ESA, ESA1, ECS-1, ECS1 and M17S1. Browse Assay Genie's current range of FLOT2 research reagents below, or read on for the biology behind the target.
FLOT2 may act as a scaffolding protein within caveolar membranes, functionally participating in the formation of caveolae or caveolae-like vesicles. Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction, so a protein that organises these domains sits close to several membrane-associated processes. FLOT2 may also be involved in epidermal cell adhesion and in epidermal structure and function.
The FLOT2 gene encodes a caveolae-associated, integral membrane protein, flotillin-2. UniProt records its subcellular locations as the cell membrane, caveolae and endosomes, consistent with a role at membrane microdomains and in vesicular compartments. It belongs to the flotillin subfamily of the band 7/mec-2 family, and HGNC places it in the Flotillins gene group. The related flotillin FLOT1 is a natural companion target for studies of this group.
RefSeq summarises the protein as thought to function in neuronal signalling. The gene has several historical aliases, including ESA, ESA1, ECS-1, ECS1 and M17S1, which you may encounter in older literature when searching for the FLOT2 protein or running a FLOT2 antibody or FLOT2 ELISA kit based search. Orthologous genes are designated Flot2 in both mouse and rat.
FLOT2 may act as a scaffold in caveolar membranes and take part in forming caveolae or caveolae-like vesicles.
Caveolae are involved in vesicular trafficking, and FLOT2 is found at the cell membrane and in endosomes.
Caveolae are domains linked to signal transduction, making FLOT2 relevant to work on membrane-associated signalling.
FLOT2 may contribute to epidermal cell adhesion and structure, and is thought to function in neuronal signalling.
FLOT2 may act as a scaffolding protein within caveolar membranes, participating in the formation of caveolae or caveolae-like vesicles. It may also be involved in epidermal cell adhesion and epidermal structure and function, and is thought to function in neuronal signalling.
The HGNC name is flotillin 2, and UniProt lists the protein as flotillin-2. Aliases and previous symbols include ESA, ESA1, ECS-1, ECS1 and M17S1. Checking all of these names helps when reviewing older publications or database entries.
Yes. Mouse and rat both have an ortholog named Flot2. In humans FLOT2 belongs to the flotillin subfamily of the band 7/mec-2 family. Check the datasheet of any product for its validated reactivity.
Other flotillin family members and caveolae-associated membrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14254; product specifications from Assay Genie datasheets.