FADS1
FADS1 (fatty acid desaturase 1) is a member of the fatty acid desaturase family, enzymes that regulate the unsaturation of fatty acids. It is also known as acyl-CoA (8-3)-desaturase, D5D, FADSD5, TU12, FADS6 and LLCDL1. Browse Assay Genie's current range of FADS1 research reagents below, or read on for the biology behind the target.
FADS1 belongs to the fatty acid desaturase type 1 family. Desaturase enzymes regulate the unsaturation of fatty acids by introducing double bonds between defined carbons of the fatty acyl chain. The protein is classified as acyl-CoA (8-3)-desaturase and carries the enzyme number EC 1.14.19.44. The UniProt annotation for this entry also records that it does not exhibit catalytic activity toward 20:3n-6, but that it may enhance FADS2 activity, pointing to a functional relationship with its neighbour in the gene family.
FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal portion with multiple membrane-spanning segments that carries the desaturase function. Both regions are characterised by conserved histidine motifs. Consistent with this membrane-embedded architecture, the FADS1 protein is annotated to the endoplasmic reticulum membrane and to the mitochondrion. The mouse and rat orthologues are both named Fads1.
The FADS1 gene sits in a cluster of FADS family genes on chromosome 11, which is thought to have arisen by gene duplication, based on the similar exon and intron organisation of its members. HGNC places it in the groups fatty acid desaturases, cytochrome b5 domain containing, and microRNA protein coding host genes. Alternative names found in the literature and databases include D5D, FADSD5, TU12, FADS6 and LLCDL1, so searches for the FADS1 gene or protein may need to cover several of these.
FADS1 is a desaturase that regulates the unsaturation of fatty acids by introducing double bonds into the fatty acyl chain.
The FADS family shares a cytochrome b5-like domain fused to a membrane-spanning desaturase region, making FADS1 a useful subject for structure and function comparison.
UniProt notes that this entry may enhance FADS2 activity, which makes it relevant to studies of cooperation within the desaturase cluster.
The FADS genes cluster on chromosome 11 and are thought to derive from gene duplication, providing a model for gene family evolution.
FADS1 is a fatty acid desaturase, a class of enzyme that regulates unsaturation of fatty acids by introducing double bonds at defined carbons of the fatty acyl chain. It is classified as acyl-CoA (8-3)-desaturase, and UniProt notes it may enhance FADS2 activity.
The HGNC-approved name is fatty acid desaturase 1, and UniProt lists acyl-CoA (8-3)-desaturase. Aliases and earlier symbols include D5D, FADSD5, TU12, FADS6 and LLCDL1. No previous HGNC names are recorded, so literature searches may need several of these terms.
Mouse and rat both have an orthologue named Fads1. In humans the gene lies in a cluster of FADS family genes thought to have arisen by gene duplication, based on similar exon and intron organisation. Check the datasheet of any product for its validated reactivity.
Other fatty acid desaturases and related lipid-metabolism enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60427; product specifications from Assay Genie datasheets.