DBNL
DBNL (drebrin like) is an adapter protein that binds F-actin and dynamin 1 (DNM1), linking the actin cytoskeleton to endocytosis. It is also known as SH3P7, HIP-55 and ABP1, and belongs to the drebrin family. Browse Assay Genie's current range of DBNL research reagents below, or read on for the biology behind the target.
DBNL is an adapter protein that binds F-actin and DNM1, and through these interactions it contributes to receptor-mediated endocytosis. It does not bind G-actin or promote actin polymerisation by itself. Instead, it acts in the reorganisation of the actin cytoskeleton and in the formation of cell projections such as neurites, in neuron morphogenesis and synapse formation, via its interaction with WASL and COBL. DBNL is also required for the formation of organised podosome rosettes.
In the immune system, DBNL may act as a common effector of antigen receptor-signalling pathways in leukocytes. It is a key component of the immunological synapse that regulates T-cell activation, bridging T-cell receptors and the actin cytoskeleton to gene activation and endocytic processes. The NCBI Gene summary adds that the DBNL gene enables cadherin binding and is predicted to be involved in Rac protein signal transduction, nervous system development and podosome assembly.
UniProt lists a broad subcellular distribution for the DBNL protein: cytoskeleton, lamellipodium, ruffles, cell cortex, podosomes, early endosomes, clathrin-coated vesicle membranes, Golgi membrane, the plasma membrane and cytosol. In neurons it is found at synapses, including the postsynaptic density, and in dendrites, neuron projections and the perikaryon. The protein belongs to the ABP1 family, and HGNC places the gene in the drebrin family and the SH3 domain containing group. HGNC also classifies it among microRNA protein coding host genes. Previous names include drebrin-like, and aliases include SH3P7, HIP-55 and ABP1.
DBNL binds F-actin and DNM1, making it a useful adapter for studying how the actin cytoskeleton is coupled to endocytic machinery.
As a component of the immunological synapse, DBNL bridges TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Through WASL and COBL, DBNL contributes to neurite formation, neuron morphogenesis and synapse formation.
DBNL is required for organised podosome rosettes, making it relevant to studies of actin-rich adhesion structures.
DBNL is an adapter protein that binds F-actin and DNM1, supporting receptor-mediated endocytosis. It helps reorganise the actin cytoskeleton, shapes neurites and synapses via WASL and COBL, is required for podosome rosettes, and links TCRs to the actin cytoskeleton at the immunological synapse.
DBNL stands for drebrin like, and UniProt calls the product drebrin-like protein. Aliases and previous symbols include SH3P7, HIP-55 and ABP1, and the previous name is drebrin-like. When searching the literature, it is worth checking each of these names.
Yes. Mouse and rat both have an ortholog named Dbnl, so the gene can be studied in common rodent models. Researchers should check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Binding partners of DBNL and other actin-cytoskeleton, endocytosis and immune synapse targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJU6; product specifications from Assay Genie datasheets.