PDE9A
PDE9A (phosphodiesterase 9A) is a high-affinity, cGMP-specific 3',5'-cyclic phosphodiesterase that hydrolyses the second messenger cGMP. It regulates natriuretic-peptide-dependent cGMP signalling in the heart and contributes to cognitive function in the brain. Browse Assay Genie's current range of PDE9A research reagents below, or read on for the biology behind the target.
PDE9A specifically hydrolyses the second messenger cGMP, a key regulator of many important physiological processes. Compared with other members of the cyclic nucleotide phosphodiesterase family, it has the highest affinity and selectivity for cGMP. In the heart it specifically regulates natriuretic-peptide-dependent cGMP signalling and acts as a regulator of cardiac hypertrophy in myocytes and muscle. It does not regulate nitric oxide-dependent cGMP in the heart. The annotation notes that further experiments are needed to confirm whether its action on natriuretic-peptide-dependent cGMP is specific to heart or a general feature of the protein. In the brain, PDE9A is involved in cognitive function, including learning and long-term memory.
The PDE9A gene encodes a member of the cyclic nucleotide phosphodiesterase family, belonging to the PDE9 subfamily, and HGNC classifies it within the phosphodiesterases gene group. The NCBI Gene summary describes the encoded protein as catalysing hydrolysis of cAMP and cGMP to their corresponding monophosphates, thereby shaping signal transduction by controlling the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been reported for this gene. The protein has been annotated in several subcellular locations, including the ruffle membrane, perinuclear cytoplasm, Golgi apparatus, endoplasmic reticulum and the sarcolemma of the cell membrane.
Researchers studying PDE9A work on cyclic nucleotide signalling in cardiac and neuronal contexts. Mouse and rat both have a Pde9a ortholog, which allows the protein to be examined in common rodent models alongside other phosphodiesterase family members such as PDE1A, PDE4A and PDE10A.
PDE9A regulates natriuretic-peptide-dependent cGMP signalling in heart and acts as a regulator of cardiac hypertrophy in myocytes and muscle.
In brain, PDE9A is involved in cognitive function, including learning and long-term memory, making it relevant to neuroscience studies.
PDE9A has the highest affinity and selectivity for cGMP among cyclic nucleotide phosphodiesterases, making it a focus for second-messenger studies.
As a PDE9 subfamily member, PDE9A supports comparative work on how phosphodiesterases control intracellular cyclic nucleotide concentrations.
PDE9A hydrolyses cGMP, a second messenger that regulates many physiological processes, and has the highest affinity and selectivity for cGMP in its family. In the heart it regulates natriuretic-peptide-dependent cGMP signalling and cardiac hypertrophy; in the brain it is involved in learning and long-term memory.
No aliases or previous symbols are listed for PDE9A; its UniProt name is high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A. The NCBI Gene summary reports multiple transcript variants that encode several different isoforms, so check the datasheet of any product for its validated reactivity.
Yes. Both mouse and rat have an ortholog named Pde9a, so the protein can be studied in standard rodent models. The human gene lies at 21q22.3. Check the datasheet of any product for its validated reactivity before choosing a species.
Other phosphodiesterase family members involved in cyclic nucleotide signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O76083; product specifications from Assay Genie datasheets.