VAMP1
VAMP1 (vesicle-associated membrane protein 1, also known as VAMP-1 or SYB1) is a member of the synaptobrevin family. It is involved in the targeting and fusion of transport vesicles to their target membrane, including synaptic vesicle docking at the presynaptic membrane. Browse Assay Genie's current range of VAMP1 research reagents below, or read on for the biology behind the target.
VAMP1 is involved in the targeting and/or fusion of transport vesicles to their target membrane. Synaptobrevins, syntaxins and the synaptosomal-associated protein SNAP25 are the main components of a protein complex that mediates the docking and/or fusion of synaptic vesicles with the presynaptic membrane, and VAMP1 belongs to this synaptobrevin group of vesicle proteins.
The protein is encoded by the VAMP1 gene and is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family, which HGNC groups as the vesicle associated membrane proteins. UniProt annotates VAMP1 at the synaptic vesicle membrane of secretory vesicles, in synaptosomes, at cytoplasmic vesicle membranes and at the mitochondrial outer membrane. Multiple alternative splice variants have been described, although the full-length nature of some variants has not been defined.
VAMP1 was previously named synaptobrevin 1, and the symbol SYB1 is still used as an alias. Mutations in the VAMP1 gene are associated with autosomal dominant spastic ataxia 1, which links the protein's role in vesicle trafficking to neurological disease. Mouse and rat each have a Vamp1 ortholog, so the protein can be studied in common rodent models. Related family members include VAMP2 and VAMP8.
VAMP1 is part of the SNARE machinery that docks and fuses synaptic vesicles with the presynaptic membrane.
As a synaptobrevin family protein, VAMP1 is involved in targeting and fusing transport vesicles to their target membranes.
Mutations in VAMP1 are associated with autosomal dominant spastic ataxia 1, making it relevant to studies of inherited ataxia.
VAMP1 acts alongside syntaxins and SNAP25 in the protein complex that underlies vesicle docking and fusion.
VAMP1 is involved in the targeting and/or fusion of transport vesicles to their target membrane. Together with syntaxins and SNAP25, synaptobrevins form a complex that mediates docking and/or fusion of synaptic vesicles with the presynaptic membrane.
VAMP1 is also written VAMP-1 and has the alias SYB1. Its previous name was synaptobrevin 1, and its HGNC full name is vesicle associated membrane protein 1. Multiple alternative splice variants have been described, though the full-length nature of some is undefined.
Mutations in the VAMP1 gene are associated with autosomal dominant spastic ataxia 1. Mouse and rat both have a Vamp1 ortholog. Check the datasheet of any product for its validated reactivity.
Other vesicle-associated membrane proteins and SNARE-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23763; product specifications from Assay Genie datasheets.