LHX2
LHX2 (LIM homeobox 2, also known as LH-2 or hLhx2) is a nuclear LIM/homeobox protein that acts as a transcriptional activator. It is involved in the control of cell differentiation in developing lymphoid and neural cell types. Browse Assay Genie's current range of LHX2 research reagents below, or read on for the biology behind the target.
LHX2 is a transcriptional regulatory protein that acts as a transcriptional activator. It stimulates the promoter of the alpha-glycoprotein gene, and it is involved in the control of cell differentiation in developing lymphoid and neural cell types. The protein is found in the nucleus, consistent with its role in regulating gene expression.
The LHX2 gene encodes a member of the LIM class homeoboxes, a large protein family whose members carry the LIM domain, a unique cysteine-rich zinc-binding domain. According to the NCBI Gene summary, the encoded protein may function as a transcriptional regulator. Mouse and rat both have an orthologous Lhx2 gene, which makes rodent models a natural route for studying the human LHX2 protein.
The LHX2 protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein. This suggests that its function has been conserved during evolution. The protein is also known as LH-2 and hLhx2, and these names may appear in older literature. Related LIM homeobox family members, such as LHX3, belong to the same gene group and are often studied alongside it when researchers examine how LIM-domain transcription factors direct cell fate.
LHX2 helps control cell differentiation in developing neural cell types, making it a relevant transcription factor for studying how neural lineages are specified.
LHX2 is involved in the differentiation of developing lymphoid cell types, so it is of interest in studies of lymphoid lineage development.
As a transcriptional activator that stimulates the alpha-glycoprotein gene promoter, LHX2 is a useful model for studying LIM homeodomain-driven gene activation.
LHX2 can rescue phenotypes caused by a related Drosophila protein, supporting comparative work on conserved developmental regulators.
LHX2 acts as a transcriptional activator in the nucleus. It stimulates the promoter of the alpha-glycoprotein gene and is involved in controlling cell differentiation in developing lymphoid and neural cell types. The NCBI Gene summary notes that it may function as a transcriptional regulator.
The official name is LIM homeobox 2, and UniProt lists the protein as LIM/homeobox protein Lhx2. Aliases include LH-2 and hLhx2. HGNC places the gene in the LIM class homeoboxes group, and no previous names are recorded.
Yes. Mouse and rat each have an orthologous Lhx2 gene. The LHX2 protein can also recapitulate or rescue phenotypes in Drosophila caused by a related protein, which suggests conserved function. Check the datasheet of any product for its validated reactivity.
Other LIM class homeobox transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50458; product specifications from Assay Genie datasheets.