USP6NL
USP6NL (USP6 N-terminal like, also known as RNTRE, RN-tre, KIAA0019 and TRE2NL) is a GTPase-activating protein that acts on Rab small GTPases. It contributes to receptor trafficking, retrograde transport to the Golgi apparatus and Golgi structural integrity. Browse Assay Genie's current range of USP6NL research reagents below, or read on for the biology behind the target.
USP6NL acts as a GTPase-activating protein for the small GTPases RAB43, RAB5A and RAB30. By stimulating GTP hydrolysis on these Rab proteins, it positively regulates GTPase activity and helps control membrane trafficking. It is involved in receptor trafficking, and in a complex with EPS8 it inhibits internalisation of EGFR.
The protein also functions in retrograde transport from the endocytic pathway to the Golgi apparatus. It is involved in moving Shiga toxin from early and recycling endosomes to the trans-Golgi network, and it is required for the structural integrity of the Golgi complex. NCBI Gene annotation describes it as enabling GTPase activator activity and small GTPase binding, and as taking part in plasma membrane to endosome transport and plasma membrane to Golgi retrograde transport. It is located in cytoplasmic vesicles and at the plasma membrane, and is active in the cytosol, while UniProt records the Golgi apparatus and cytoplasmic vesicles as its subcellular locations.
The USP6NL gene encodes USP6 N-terminal-like protein and is classed by HGNC in the TBC1 domain family members. Despite the name, the symbol refers to similarity to the N-terminal region of USP6 rather than to a deubiquitinase role. Alternative names include RNTRE, RN-tre, KIAA0019 and TRE2NL, and an earlier HGNC entry, USP6NL intronic transcript 1, was a non-protein-coding transcript. The mouse ortholog is Usp6nl.
USP6NL acts as a GTPase-activating protein for RAB5A, RAB43 and RAB30, making it a useful node for studying Rab-regulated vesicle transport.
The protein is involved in retrograde transport from endosomes to the Golgi, including the transport of Shiga toxin to the trans-Golgi network.
In complex with EPS8, USP6NL inhibits internalisation of EGFR, linking it to receptor trafficking and signalling research.
USP6NL is required for the structural integrity of the Golgi complex, which makes it relevant to studies of Golgi architecture.
USP6NL is a GTPase-activating protein for RAB43, RAB5A and RAB30. It is involved in receptor trafficking and retrograde transport from the endocytic pathway to the Golgi apparatus, and it is required for Golgi structural integrity. With EPS8, it inhibits EGFR internalisation.
USP6NL stands for USP6 N-terminal like. Aliases include RNTRE, RN-tre, KIAA0019 and TRE2NL, and the UniProt name is USP6 N-terminal-like protein. USP6NL intronic transcript 1 (USP6NL-IT1) was a previous name for a non-protein-coding transcript. HGNC places the gene in the TBC1 domain family.
Yes, the mouse ortholog is Usp6nl. The source data here do not identify a rat ortholog. For antibody or ELISA kit use in a given species, check the datasheet of any product for its validated reactivity.
Other ubiquitin-specific protease family targets that share part of the USP naming with USP6NL, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92738; product specifications from Assay Genie datasheets.