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SAMD7
SAMD7 (sterile alpha motif domain containing 7) is a component of a Polycomb group PRC1-like complex that silences nonrod gene expression in developing rod photoreceptor cells. It is also known by the alias DKFZp686E1583 and is implicated in macular degeneration. Browse Assay Genie's current range of SAMD7 research reagents below, or read on for the biology behind the target.
SAMD7 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex is essential for establishing rod photoreceptor cell identity and function, because it silences nonrod gene expression in developing rod photoreceptor cells. Through its association with the PRC1-like complex, SAMD7 promotes the repressive epigenetic marks H3K27me3 and H2AK119ub at nonrod genes, silencing their transcription. SAMD7 also represses Crx-controlled photoreceptor-specific gene expression.
The SAMD7 protein is annotated in UniProt as localising to the nucleus and the cytoplasm. NCBI Gene describes it as predicted to enable DNA-binding transcription repressor activity (RNA polymerase II-specific), chromatin binding and histone binding. It is also predicted to be involved in negative regulation of DNA-templated transcription, epigenetic negative regulation of gene expression and retinal rod cell development. These predicted activities are consistent with its role in the PRC1 complex.
HGNC places the SAMD7 gene in the sterile alpha motif domain containing group, and DKFZp686E1583 is a recorded alias. The mouse ortholog is Samd7. SAMD7 is implicated in macular degeneration, which makes it a point of interest for studies of retinal development and photoreceptor gene regulation.
SAMD7 contributes to retinal rod cell development and to establishing rod photoreceptor identity, so it is relevant to studies of photoreceptor differentiation.
As part of a PRC1-like complex, SAMD7 promotes H3K27me3 and H2AK119ub marks at nonrod genes, making it a useful subject for Polycomb mechanism studies.
SAMD7 represses Crx-controlled photoreceptor-specific gene expression, offering a route into how transcription factor activity is restrained during cell fate specification.
SAMD7 is implicated in macular degeneration, linking its regulatory function in photoreceptors to investigations of retinal disease.
SAMD7 is a component of a Polycomb group PRC1-like complex in developing rod photoreceptor cells. It helps establish rod identity by silencing nonrod genes, promoting H3K27me3 and H2AK119ub marks, and it represses Crx-controlled photoreceptor-specific gene expression.
The approved HGNC name is sterile alpha motif domain containing 7, and UniProt lists the protein as sterile alpha motif domain-containing protein 7. DKFZp686E1583 is a recorded alias. No previous symbols or names are listed in HGNC for this gene.
A mouse ortholog, Samd7, exists. NCBI Gene reports that SAMD7 is implicated in macular degeneration and is predicted to function in retinal rod cell development. Check the datasheet of any product for its validated reactivity.
Other sterile alpha motif domain containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z3H4; product specifications from Assay Genie datasheets.
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