TRPM4
TRPM4 (transient receptor potential cation channel subfamily M member 4) is a calcium-activated, nonselective cation channel of the TRPM subfamily. It carries monovalent cations across membranes and depolarises the cell, and it is also known by the former alias FLJ20041. Browse Assay Genie's current range of TRPM4 research reagents below, or read on for the biology behind the target.
TRPM4 is a calcium-activated nonselective ion channel. It mediates the transport of monovalent cations across membranes, and this flow of charge depolarises the membrane. Its activity rises as the intracellular calcium concentration increases, so the channel converts changes in cytosolic calcium into changes in membrane potential. A defining feature is that, although calcium controls its gating, the TRPM4 channel does not itself transport calcium.
The TRPM4 gene encodes a protein that belongs to the transient receptor potential (TRP) family, listed under transporter classification TC 1.A.4. Within that family it sits in the LTrpC subfamily, which corresponds to the TRPM group, and it forms its own TRPM4 sub-subfamily. HGNC places the gene in the transient receptor potential cation channel subfamily M gene group. UniProt records the protein in the cell membrane, the endoplasmic reticulum and the Golgi apparatus. Orthologous genes, both named Trpm4, are annotated in mouse and rat, which allows comparative work in rodent models.
The gene was formerly listed as transient receptor potential cation channel, subfamily M, member 4, and the older alias FLJ20041 still appears in some records and publications. Other TRPM family members, including TRPM1, TRPM6, TRPM7 and TRPM8, share the subfamily name but differ in their individual properties. For TRPM4 research, the key points are its dependence on intracellular calcium, its selectivity for monovalent cations and its effect on membrane depolarisation. These properties make it a useful reference when studying how calcium signals are coupled to electrical activity in cells.
TRPM4 is a calcium-activated channel that passes monovalent cations, making it a model for studying how intracellular calcium is coupled to membrane depolarisation.
Channel activity increases with intracellular calcium yet the channel does not transport calcium, so TRPM4 is relevant to how calcium signals are decoded.
By mediating monovalent cation transport, TRPM4 depolarises the membrane, which makes it a focus for work on cellular excitability and electrical signalling.
TRPM4 belongs to the TRPM subfamily of TRP channels, which allows comparison with related members such as TRPM7 and TRPM8.
TRPM4 is a calcium-activated nonselective ion channel. It mediates transport of monovalent cations across membranes, which depolarises the membrane. Its activity increases as intracellular calcium rises, but the channel does not transport calcium itself. UniProt lists it in the cell membrane, endoplasmic reticulum and Golgi apparatus.
The HGNC full name is transient receptor potential cation channel subfamily M member 4, and the previous name used a comma-separated subfamily format. The alias FLJ20041 is also recorded. In family terms, TRPM4 is part of the LTrpC subfamily and its own TRPM4 sub-subfamily.
Yes. Orthologous genes named Trpm4 are annotated in both mouse and rat, so findings can be compared across human and rodent systems. As with any cross-species work, check the datasheet of any product for its validated reactivity before use.
Other TRPM subfamily channels and related transient receptor potential cation channel targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TD43; product specifications from Assay Genie datasheets.