SLC22A1
SLC22A1, also known as OCT1, is a polyspecific organic cation transporter of the plasma membrane. It contributes to the elimination of endogenous small organic cations, drugs and environmental toxins in organs such as the liver, kidney and intestine. Browse Assay Genie's current range of SLC22A1 research reagents below, or read on for the biology behind the target.
SLC22A1 (solute carrier family 22 member 1, also called OCT1) belongs to the organic cation transporter family within the major facilitator superfamily. Polyspecific organic cation transporters of this kind in the liver, kidney, intestine and other organs are critical for the elimination of many endogenous small organic cations, as well as a wide array of drugs and environmental toxins. Unlike some related transporters, SLC22A1 is not able to take up 1-methyl-4-phenylpyridinium (MPP+).
The SLC22A1 protein is an integral plasma membrane protein with twelve putative transmembrane domains. UniProt records it at several membrane surfaces: basolateral, apical, lateral and basal cell membrane. The SLC22A1 gene is one of three similar cation transporter genes found in a cluster on chromosome 6. Two transcript variants encoding two different isoforms have been described, but only the longer variant encodes a functional transporter.
The gene was previously named solute carrier family 22 (organic cation transporter), member 1, and HGNC places it in the solute carrier family 22 gene group. Mouse and rat both carry an orthologous gene, Slc22a1, which allows comparative work on cation transport across species. Researchers studying SLC22A1 are typically interested in drug handling, xenobiotic clearance and the wider biology of solute carriers, and they use tools such as an SLC22A1 antibody or SLC22A1 ELISA kit to examine expression of this transporter.
SLC22A1 helps eliminate a wide array of drugs, making it a relevant transporter for studies of how small organic cation drugs cross cell membranes.
Organic cation transporters such as SLC22A1 contribute to removal of environmental toxins, so the protein is studied in detoxification and clearance.
SLC22A1 acts in the liver, kidney and intestine, where polyspecific cation transport supports elimination of endogenous small organic cations.
A twelve-transmembrane major facilitator superfamily member with polarised membrane localisation, SLC22A1 is a useful model for solute carrier structure and function.
SLC22A1 is a plasma membrane transporter of organic cations. Polyspecific transporters of this type in the liver, kidney and intestine help eliminate endogenous small organic cations, drugs and environmental toxins. Notably, SLC22A1 is not able to take up 1-methyl-4-phenylpyridinium (MPP+).
Yes. OCT1 is an alias of SLC22A1, and the gene was formerly named solute carrier family 22 (organic cation transporter), member 1. Two transcript variants encoding different isoforms are known, but only the longer variant encodes a functional transporter.
Both mouse and rat have an ortholog named Slc22a1. In humans the gene sits in a cluster of three similar cation transporter genes on chromosome 6. Check the datasheet of any product for its validated reactivity.
Other solute carrier family members and membrane transporters with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15245; product specifications from Assay Genie datasheets.