FASLG
FASLG (Fas ligand, also known as FasL, CD95L, CD178 and TNFSF6) is a transmembrane member of the tumour necrosis factor superfamily. Its primary function is to induce apoptosis by binding to FAS, making it central to immune regulation. Browse Assay Genie's current range of FASLG research reagents below, or read on for the biology behind the target.
FASLG is a transmembrane protein whose primary function is the induction of apoptosis, triggered by binding to its receptor FAS. The FAS/FASLG signalling pathway is essential for immune system regulation. It contributes to activation-induced cell death (AICD) of T cells and to cytotoxic T lymphocyte induced cell death. A cytoplasmic form of the protein has also been annotated as inducing inhibition of gene transcription.
The FASLG gene encodes a member of the tumour necrosis factor family, and the protein is formally named tumour necrosis factor ligand superfamily member 6. UniProt records it in several compartments: the cell membrane, cytoplasmic vesicle lumen, lysosome lumen, secreted fraction and the nucleus. Alternatively spliced transcript variants have been described for the gene. Orthologues are present in mouse and rat, both designated Faslg, which allows the pathway to be studied in rodent models.
The protein has gone by several names, including apoptosis (APO-1) antigen ligand 1, APT1LG1, APTL, FasL, CD95L, CD178 and TNFSF6. HGNC places it among the CD molecules, the tumour necrosis factor superfamily and the death inducing signalling complex gene group. FASLG has been implicated in the progression of several cancers, and defects in the gene may be related to some cases of systemic lupus erythematosus (SLE). Researchers working on FASLG, whether through an FASLG antibody, FASLG protein or FASLG ELISA kit, typically focus on apoptosis and immune tolerance.
FASLG induces apoptosis by binding FAS, making it a core ligand for studying death receptor signalling.
The FAS/FASLG pathway mediates activation-induced cell death of T cells and cytotoxic T lymphocyte induced cell death.
FASLG has been implicated in the progression of several cancers, prompting study of its role in tumour biology.
Defects in FASLG may be related to some cases of systemic lupus erythematosus, linking it to immune dysregulation.
FASLG is a transmembrane ligand whose primary function is to induce apoptosis by binding FAS. The FAS/FASLG pathway is essential for immune regulation, including activation-induced cell death of T cells and cytotoxic T lymphocyte induced cell death.
FASLG is also called Fas ligand, FasL, CD95L, CD178, TNFSF6, APTL and APT1LG1. UniProt names it tumour necrosis factor ligand superfamily member 6. Alternatively spliced transcript variants have been described, so check the datasheet of any product for its validated reactivity.
FASLG has been implicated in the progression of several cancers. Defects in the gene may be related to some cases of systemic lupus erythematosus. Mouse and rat carry orthologues named Faslg, which are used to study this pathway.
Fas receptor partners, other TNF superfamily ligands and death-inducing signalling complex components relevant to apoptosis research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P48023; product specifications from Assay Genie datasheets.