RPS6KA2
RPS6KA2 (ribosomal protein S6 kinase A2, also known as RSK3 and HU-2) is a serine/threonine-protein kinase that acts downstream of ERK signalling. It mediates mitogenic and stress-induced activation of transcription factors and regulates translation, proliferation, survival and differentiation. Browse Assay Genie's current range of RPS6KA2 research reagents below, or read on for the biology behind the target.
RPS6KA2 is a serine/threonine-protein kinase that acts downstream of ERK signalling, specifically MAPK1/ERK2 and MAPK3/ERK1. Through this route it mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and contributes to cellular proliferation, survival and differentiation. The enzyme catalyses the phosphorylation of serine and threonine residues on its substrates, and the NCBI Gene summary notes that these include members of the mitogen-activated protein kinase (MAPK) signalling pathway. Its activity has been implicated in controlling cell growth and differentiation.
The RPS6KA2 gene encodes a member of the RSK (ribosomal S6 kinase) family. The protein contains two non-identical kinase catalytic domains, a hallmark of the RSK family. It belongs to the protein kinase superfamily, the AGC Ser/Thr protein kinase family and the S6 kinase subfamily. UniProt records its subcellular localisation as nuclear and cytoplasmic, and alternative splice variants encoding different isoforms have been characterised. Researchers working with the RPS6KA2 gene or RPS6KA2 protein will find the mouse ortholog named Rps6ka2.
HGNC classifies the gene within the MAPK activated protein kinases, the ribosomal protein S6 kinase family, and the group of microRNA protein coding host genes. Besides RSK3 and HU-2, the gene was previously named ribosomal protein S6 kinase, 90kD, polypeptide 2. In terms of disease relevance, UniProt notes that RPS6KA2 may function as a tumour suppressor in epithelial ovarian cancer cells.
RPS6KA2 acts downstream of ERK1 and ERK2, making it a useful readout of how mitogenic and stress signals are relayed to effectors.
The kinase regulates translation, so it is studied in work on how growth signals are coupled to protein synthesis.
Its activity has been implicated in controlling cell growth, proliferation, survival and differentiation across cellular models.
RPS6KA2 may act as a tumour suppressor in epithelial ovarian cancer cells, motivating studies of its role in tumour biology.
RPS6KA2 is a serine/threonine kinase that acts downstream of ERK1 and ERK2. It mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and contributes to cell proliferation, survival and differentiation. It is found in both the nucleus and the cytoplasm.
RPS6KA2 is also known as RSK3 and HU-2, and its protein name in UniProt is ribosomal protein S6 kinase alpha-2. An earlier HGNC name was ribosomal protein S6 kinase, 90kD, polypeptide 2. Alternative splicing produces different isoforms, so check the datasheet of any product for its validated reactivity.
UniProt reports that RPS6KA2 may function as a tumour suppressor in epithelial ovarian cancer cells. The NCBI Gene summary links its activity to control of cell growth and differentiation. A mouse ortholog, Rps6ka2, exists for comparative studies.
Other ribosomal S6 kinase family members, MAPK-activated kinases and ribosomal protein targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15349; product specifications from Assay Genie datasheets.