TINAGL1
TINAGL1 (tubulointerstitial nephritis antigen like 1) is a secreted, non-catalytic member of the peptidase C1 family. It is also known as P3ECSL, LIECG3, ARG1, TINAGRP and LCN7, and it is similar in sequence to tubulointerstitial nephritis antigen. Browse Assay Genie's current range of TINAGL1 research reagents below, or read on for the biology behind the target.
TINAGL1 is a secreted protein that belongs to the peptidase C1 family but is annotated as non-catalytic, so it is not expected to act as an active peptidase. UniProt annotation suggests that it may be implicated in adrenocortical zonation and in the mechanisms that repress CYP11B1 gene expression in adrenocortical cells. These roles are described as possible rather than established, and the detailed molecular mechanism is not defined in the source annotation.
The TINAGL1 gene encodes a protein whose sequence is similar to tubulointerstitial nephritis antigen. That protein is a secreted glycoprotein recognised by antibodies in some types of immune-related tubulointerstitial nephritis. According to the NCBI Gene summary, three transcript variants encoding different isoforms have been described for the TINAGL1 gene. The mouse and rat orthologs are both named Tinagl1.
The gene has carried several names. HGNC lists the previous names lipocalin 7 and TINAG-like 1, and the aliases P3ECSL, LIECG3, ARG1, TINAGRP and LCN7 appear in the literature and databases. Researchers should check which name a publication or reagent uses, because ARG1 and LCN7 can be confused with unrelated genes. HGNC places TINAGL1 in the peptidase family C1 gene group.
TINAGL1 may be implicated in adrenocortical zonation, making it a candidate for studies of how adrenal cortex regions are organised.
UniProt annotation links TINAGL1 to mechanisms that repress CYP11B1 expression in adrenocortical cells.
TINAGL1 resembles tubulointerstitial nephritis antigen, a secreted glycoprotein targeted by antibodies in some immune-related forms of the disease.
As a non-catalytic peptidase C1 family member, TINAGL1 is useful for comparing catalytic and non-catalytic relatives within the family.
The function of TINAGL1 is not fully defined. UniProt states that it may be implicated in adrenocortical zonation and in repressing CYP11B1 gene expression in adrenocortical cells. It is a secreted, non-catalytic member of the peptidase C1 family, so it is not expected to cleave substrates.
TINAGL1 is also called P3ECSL, LIECG3, ARG1, TINAGRP and LCN7. Previous names include lipocalin 7 and TINAG-like 1. NCBI Gene reports three transcript variants that encode different isoforms, so check which isoform a given reagent or study addresses.
Mouse and rat both have an ortholog named Tinagl1. In humans, the protein is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein linked to some immune-related tubulointerstitial nephritis. Check the datasheet of any product for its validated reactivity.
Related peptidase C1 family members, the tubulointerstitial nephritis antigen and adrenocortical gene-expression markers.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9GZM7; product specifications from Assay Genie datasheets.