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AATK
AATK (apoptosis-associated tyrosine kinase) is a member of the lemur tail kinase family, encoded by the gene with the HGNC symbol LMTK1. It is also known as AATYK, KIAA0641, LMR1, AATYK1 and PPP1R77, and may be involved in neuronal differentiation. Browse Assay Genie's current range of AATK research reagents below, or read on for the biology behind the target.
AATK is a protein kinase that belongs to the protein kinase superfamily and the Tyr protein kinase family, and it carries the enzyme classification EC 2.7.11.1. UniProt annotates the protein as serine/threonine-protein kinase LMTK1 and notes that it may be involved in neuronal differentiation. In the cell it is found at the membrane and in the cytoplasm, including the perinuclear region.
According to the NCBI Gene summary, the AATK protein contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. The AATK gene is induced during apoptosis, and its expression may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. The gene has also been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been described. The mouse ortholog is Aatk.
The official HGNC name is lemur tail kinase 1, with the symbol LMTK1. The earlier name, apoptosis associated tyrosine kinase, explains the AATK and AATYK designations still used in the literature. HGNC places the gene in several groups: the lemur tail kinase family, the protein phosphatase 1 regulatory subunits (hence the alias PPP1R77), and the microRNA protein coding host genes. LMTK3 is a related member of the lemur tail kinase family.
AATK may be involved in neuronal differentiation and has been shown to drive differentiation in a neuroblastoma cell line, making it a useful target in neurodevelopment studies.
The AATK gene is induced during apoptosis, so it is studied in programmed cell death and the cellular responses that accompany it.
AATK expression may be required for growth arrest and apoptosis of myeloid precursor cells, linking it to myeloid cell fate studies.
As a member of the lemur tail kinase family with a tyrosine kinase domain, AATK is relevant to work on kinase function and signalling.
UniProt states that AATK may be involved in neuronal differentiation. The NCBI Gene summary adds that the gene is induced during apoptosis, may be needed for growth arrest and apoptosis of myeloid precursor cells, and produces neuronal differentiation in a neuroblastoma cell line.
The gene symbol is LMTK1 (lemur tail kinase 1), with aliases AATYK, KIAA0641, LMR1, AATYK1 and PPP1R77. AATK comes from the previous name, apoptosis associated tyrosine kinase. Two transcript variants encoding different isoforms have been reported.
A mouse ortholog, Aatk, is recorded for this gene, so rodent models can be used to study it. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other lemur tail kinase family members and related kinase targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6ZMQ8; product specifications from Assay Genie datasheets.
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