CD36
CD36, also known as platelet glycoprotein 4, SCARB3, GPIV, FAT, GP4, GP3B and GPIIIB, is a cell-surface scavenger receptor of the CD36 family. It is the fourth major glycoprotein of the platelet surface and binds thrombospondin, collagen, anionic phospholipids, oxidized LDL and long chain fatty acids. Browse Assay Genie's current range of CD36 research reagents below, or read on for the biology behind the target.
CD36 is a membrane glycoprotein that acts as a receptor for thrombospondin in platelets and various cell lines. Because thrombospondins are widely distributed proteins involved in a variety of adhesive processes, CD36 may have important functions as a cell adhesion molecule. It also binds collagen, anionic phospholipids and oxidized LDL, and it binds long chain fatty acids, where it may function in fatty acid transport or as a regulator of that transport.
CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. It also mediates the internalisation of particles independently of TLR signalling. UniProt places the protein at the cell membrane, in membrane rafts, at the Golgi apparatus and at the apical cell membrane, and assigns it to the CD36 family. The mouse and rat orthologs are both named Cd36, which makes rodent models a practical route for studying its biology.
The CD36 gene is annotated by HGNC within the groups blood group antigens, CD molecules and scavenger receptors. Its names reflect its history: earlier designations include CD36 antigen (collagen type I receptor, thrombospondin receptor) and CD36 molecule (thrombospondin receptor). Mutations in the gene cause platelet glycoprotein deficiency, and multiple alternatively spliced transcript variants have been described. Researchers studying CD36 protein levels, ligand binding or expression often use an anti-CD36 antibody or a CD36 ELISA kit as part of their workflow.
CD36 is a major platelet surface glycoprotein and a thrombospondin receptor, making it relevant to studies of platelet adhesion.
CD36 binds long chain fatty acids and may transport or regulate their transport, which links it to lipid handling research.
As a scavenger receptor that binds oxidized LDL and anionic phospholipids, CD36 is a focus for work on lipoprotein recognition.
CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes, supporting research on parasite binding to host cells.
CD36 is a receptor for thrombospondin, collagen, anionic phospholipids and oxidized LDL, and it binds long chain fatty acids. It may act as a cell adhesion molecule and in fatty acid transport. It also mediates internalisation of particles independently of TLR signalling.
CD36 is also called platelet glycoprotein 4, SCARB3, GPIV, FAT, GP4, GP3B and GPIIIB. Earlier names include CD36 antigen (collagen type I receptor, thrombospondin receptor). The official HGNC name is CD36 molecule (CD36 blood group).
Mutations in the CD36 gene cause platelet glycoprotein deficiency, and the protein mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mouse and rat both have a Cd36 ortholog. Check the datasheet of any product for its validated reactivity.
Other CD molecules, scavenger receptors and adhesion-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P16671; product specifications from Assay Genie datasheets.