GSDMD
GSDMD (gasdermin D, also known as GSDMDC1, DF5L and FLJ12150) is a member of the gasdermin family. After cleavage it moves to the plasma membrane and forms pores, and it has been suggested to act as a tumour suppressor. Browse Assay Genie's current range of GSDMD research reagents below, or read on for the biology behind the target.
GSDMD is produced by cleavage, and the UniProt annotation names cleavage by papain allergen as one route. After cleavage, the protein moves to the plasma membrane and homooligomerises within the membrane. There it forms pores with an inner diameter of 10-15 nanometres. These pores allow the specific release of mature interleukin-33 (IL-33), which promotes a type 2 inflammatory immune response.
The GSDMD gene encodes gasdermin D, listed by UniProt as Gasdermin-D. It belongs to the gasdermin family, which HGNC groups as the Gasdermins. According to the NCBI Gene summary, members of this family appear to play a role in regulating epithelial proliferation. Alternatively spliced transcript variants have been described for the GSDMD gene. UniProt records the protein in several locations: cytosol, inflammasome, cell membrane, secreted, mitochondrion membrane and nucleus.
Gasdermin D has been suggested to act as a tumour suppressor. The gene was previously named gasdermin domain containing 1, and the aliases GSDMDC1, DF5L and FLJ12150 are still found in the literature. The mouse ortholog is Gsdmd. Researchers studying membrane pores, cytokine release and epithelial biology use GSDMD as a target, including through GSDMD antibody and GSDMD ELISA kit based approaches.
Cleaved GSDMD homooligomerises in the plasma membrane to form pores of 10-15 nm inner diameter, making it a model for studying membrane pore assembly.
GSDMD pores allow the specific release of mature IL-33, linking the protein to the study of unconventional cytokine secretion.
Release of IL-33 through GSDMD pores promotes a type 2 inflammatory immune response, relevant to allergen-driven immunology.
Gasdermin family members appear to regulate epithelial proliferation, and gasdermin D has been suggested to act as a tumour suppressor.
After cleavage, for example by papain allergen, GSDMD moves to the plasma membrane and homooligomerises to form pores of 10-15 nm inner diameter. These pores allow the specific release of mature IL-33, promoting a type 2 inflammatory immune response.
GSDMD stands for gasdermin D, listed by UniProt as Gasdermin-D. Aliases and previous symbols include GSDMDC1, DF5L and FLJ12150, and the earlier gene name was gasdermin domain containing 1. NCBI notes that alternatively spliced transcript variants have been described.
NCBI Gene reports that gasdermin D has been suggested to act as a tumour suppressor, and the gasdermin family appears to regulate epithelial proliferation. The mouse ortholog is Gsdmd; check the datasheet of any product for its validated reactivity.
Other gasdermin family members and the cytokine released through GSDMD pores, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P57764; product specifications from Assay Genie datasheets.