PLSCR3
PLSCR3 (phospholipid scramblase 3) is a member of the phospholipid scramblase family that moves phospholipids between the inner and outer mitochondrial membranes. It contributes to mitochondrial respiratory function, morphology and the apoptotic response. Browse Assay Genie's current range of PLSCR3 research reagents below, or read on for the biology behind the target.
PLSCR3 catalyses calcium-induced, ATP-independent, rapid bidirectional and non-specific movement of phospholipids, a process known as lipid scrambling or lipid flip-flop, between the inner and outer membranes of the mitochondria. It plays an important role in mitochondrial respiratory function, morphology and apoptotic response, and it regulates both the de novo biosynthesis of cardiolipin and its resynthesis.
A key activity of PLSCR3 is the translocation of cardiolipin from the mitochondrial inner membrane to the outer membrane. This enhances t-Bid-induced cytochrome c release and apoptosis. PLSCR3 also enhances TNFSF10-induced apoptosis by regulating cardiolipin distribution in the mitochondrial membrane, which increases the release of apoptogenic factors and amplifies caspase activity.
The PLSCR3 protein belongs to the phospholipid scramblase family, the HGNC gene group that also includes PLSCR1. UniProt lists it in the mitochondrion membrane, mitochondrial inner membrane and nucleus. NCBI Gene describes calcium-dependent protein binding, metal ion binding and phospholipid scramblase activity, with involvement in apoptotic process, mitochondrial membrane organisation and regulation of cytochrome c release from mitochondria. The PLSCR3 gene has mouse and rat orthologs, both named Plscr3.
PLSCR3 amplifies t-Bid- and TNFSF10-induced apoptosis through cardiolipin redistribution, cytochrome c release and increased caspase activity.
It mediates calcium-induced phospholipid flip-flop between the inner and outer mitochondrial membranes and contributes to mitochondrial membrane organisation.
PLSCR3 regulates cardiolipin de novo biosynthesis and resynthesis, making it relevant to studies of cardiolipin distribution in mitochondria.
The protein influences mitochondrial respiratory function and morphology, linking lipid scrambling to the maintenance of mitochondrial integrity.
PLSCR3 catalyses calcium-induced, ATP-independent scrambling of phospholipids between the inner and outer mitochondrial membranes. It supports respiratory function and mitochondrial morphology, and it moves cardiolipin to the outer membrane, which enhances t-Bid-induced cytochrome c release and apoptosis.
PLSCR3 stands for phospholipid scramblase 3. HGNC lists no alternative aliases or previous symbols for it. It belongs to the phospholipid scramblase family, and PLSCR1 is a related family member. Researchers may also search by the UniProt entry name, Phospholipid scramblase 3.
Yes. Mouse and rat both have an ortholog named Plscr3, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Other phospholipid scramblase family members and related mitochondrial and apoptosis targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NRY6; product specifications from Assay Genie datasheets.