CD39
CD39, encoded by the ENTPD1 gene, is a plasma membrane ectonucleotidase that hydrolyses extracellular ATP and ADP to AMP. It is also known as NTPDase-1, ATPDase and ATP-DPH, and it helps regulate extracellular nucleotide levels. Browse Assay Genie's current range of CD39 research reagents below, or read on for the biology behind the target.
CD39 catalyses the hydrolysis of nucleoside triphosphates (NTPs) and nucleoside diphosphates (NDPs). The enzyme removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates via NDP intermediates. In this way it contributes to the regulation of extracellular nucleotide levels. By hydrolysing proinflammatory ATP and platelet-activating ADP to AMP, CD39 blocks platelet aggregation and supports blood flow.
The ENTPD1 gene encodes a plasma membrane protein that belongs to the GDA1/CD39 NTPase family. UniProt places it in the membrane, including caveolae. HGNC classifies it within the CD molecules and the ectonucleoside triphosphate diphosphohydrolase family. NCBI Gene reports that several transcript variants encoding different isoforms have been found. Mouse and rat both carry an orthologous Entpd1 gene.
The protein has several names in the literature: ATP-DPH, NTPDase-1 and ATPDase describe its enzymatic activity, while CD39 is its cluster-of-differentiation designation. SPG64 is also listed as an alias for the gene. NCBI Gene notes that inhibiting the activity of this protein may confer anticancer benefits, which makes the CD39 protein a subject of interest in studies of extracellular ATP and ADP signalling.
CD39 regulates extracellular nucleotide levels by converting ATP and ADP to AMP, making it a key enzyme for studying nucleotide-mediated signalling.
By hydrolysing platelet-activating ADP, CD39 blocks platelet aggregation and supports blood flow, so it is studied in platelet biology.
CD39 hydrolyses proinflammatory extracellular ATP, linking this ectonucleotidase to the control of inflammatory nucleotide signals.
NCBI Gene notes that inhibiting CD39 activity may confer anticancer benefits, motivating work on its role in tumour settings.
CD39 is an ectonucleotidase that sequentially removes phosphate groups from nucleoside triphosphates and diphosphates, converting them to monophosphates. It hydrolyses proinflammatory ATP and platelet-activating ADP to AMP, which blocks platelet aggregation and supports blood flow. Check the datasheet of any product for its validated reactivity.
The gene symbol is ENTPD1, and the protein is also called ATP-DPH, NTPDase-1 and ATPDase. SPG64 is listed as an alias too. The full name is ectonucleoside triphosphate diphosphohydrolase 1. NCBI Gene reports several transcript variants encoding different isoforms.
Yes. Both mouse and rat have an ortholog named Entpd1. In humans, CD39 belongs to the GDA1/CD39 NTPase family and the wider ectonucleoside triphosphate diphosphohydrolase family, which includes related genes such as ENTPD2, ENTPD5 and ENTPD7.
Other members of the ectonucleoside triphosphate diphosphohydrolase family involved in extracellular nucleotide metabolism.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49961; product specifications from Assay Genie datasheets.