CD58
CD58, also known as LFA-3 (lymphocyte function-associated antigen 3), is a cell-surface member of the immunoglobulin superfamily. It is the ligand of the T-lymphocyte glycoprotein CD2 and contributes to T-lymphocyte adhesion and activation. Browse Assay Genie's current range of CD58 research reagents below, or read on for the biology behind the target.
CD58 is a ligand of the T-lymphocyte CD2 glycoprotein. The CD58/CD2 interaction mediates several cell-cell contacts: thymocyte interactions with thymic epithelial cells, antigen-independent and antigen-dependent interactions of T-lymphocytes with target cells and antigen-presenting cells, and the rosetting of T-lymphocytes with erythrocytes. The LFA-3/CD2 interaction may also prime a response in both the CD2-positive and LFA-3-positive cells, so engagement can act in both directions. Together, these roles place the protein in both the adhesion and the activation of T lymphocytes.
The CD58 gene encodes a member of the immunoglobulin superfamily. The mature protein is localised to the plasma membrane, and alternatively spliced transcript variants have been described. HGNC classifies the gene within the CD molecules and the Ig-like cell adhesion molecule family. It is also listed among the microRNA protein coding host genes. Researchers who study the CD58 protein therefore work at the point where adhesion and signalling meet in T-cell biology.
The protein is known by two names. UniProt records it as lymphocyte function-associated antigen 3, abbreviated LFA-3 (alias LFA3). HGNC lists the previous name as CD58 antigen. Both names are common in the literature, and it helps to search under each when reviewing CD58 antibody, CD58 ELISA kit or CD58 protein studies, since older papers often use LFA-3 only.
CD58 is a ligand of CD2 and functions in the adhesion of T lymphocytes to target cells and antigen-presenting cells.
The LFA-3/CD2 interaction may prime responses in both CD2-positive and LFA-3-positive cells, making CD58 relevant to activation research.
The CD58/CD2 interaction helps mediate thymocyte interactions with thymic epithelial cells, which is relevant to T-cell maturation.
As an Ig-like cell adhesion molecule at the plasma membrane, CD58 is a useful model for cell-surface recognition between immune cells.
CD58 is a ligand of the T-lymphocyte CD2 glycoprotein. This interaction mediates thymocyte contact with thymic epithelial cells, T-lymphocyte contact with target and antigen-presenting cells, and T-lymphocyte rosetting with erythrocytes. It may also prime responses in both CD2-positive and LFA-3-positive cells.
Yes. CD58 is also called LFA-3, or lymphocyte function-associated antigen 3, and its HGNC alias is LFA3. The previous HGNC name was CD58 antigen. Alternatively spliced transcript variants have been described for the gene, so check the datasheet of any product for its validated reactivity.
CD58 is a member of the immunoglobulin superfamily. HGNC places the gene in the CD molecules and the Ig-like cell adhesion molecule family. The encoded protein is localised to the plasma membrane, where it engages CD2 on T lymphocytes.
Other CD molecules, Ig-superfamily adhesion proteins and immune cell-surface markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P19256; product specifications from Assay Genie datasheets.