RELT
RELT (RELT TNF receptor, also known as TNFRSF19L and FLJ14993) is a member of the tumour necrosis factor receptor superfamily and the founding member of the RELT family. It is linked to NF-kappaB and MAP kinase signalling, T-cell proliferation and enamel formation. Browse Assay Genie's current range of RELT research reagents below, or read on for the biology behind the target.
RELT is a receptor of the tumour necrosis factor (TNF) receptor superfamily. It has been shown to activate the NF-kappaB pathway and to selectively bind TNF receptor-associated factor 1 (TRAF1). When overexpressed, it induces activation of the MAPK14/p38 and MAPK8/JNK MAP kinase cascades. It may also play a role in apoptosis.
RELT is capable of stimulating T-cell proliferation in the presence of CD3 signalling, which suggests a regulatory role in immune response. The receptor is especially abundant in haematologic tissues. UniProt also records an involvement in dental enamel formation. The protein is found at the cell membrane, in the cytoplasm and in the perinuclear region of the cytoplasm. Studies of the RELT protein therefore span immune signalling, cell death pathways and tooth development.
The RELT gene is classified by HGNC within the tumour necrosis factor receptor superfamily and the RELT family. Earlier names include tumour necrosis factor receptor superfamily, member 19-like (TNFRSF19L), and the gene has a mouse ortholog, Relt. Two alternatively spliced transcript variants have been reported, and both encode the same protein.
RELT has been shown to activate the NF-kappaB pathway, making it a useful receptor for studying TNF superfamily signal transduction.
Overexpressed RELT induces the p38 (MAPK14) and JNK (MAPK8) cascades, which supports work on stress-activated kinase signalling.
RELT stimulates T-cell proliferation in the presence of CD3 signalling, pointing to a regulatory role in immune response.
RELT may play a role in apoptosis and is involved in dental enamel formation, linking cell death and tooth development.
RELT is a TNF receptor superfamily member that activates the NF-kappaB pathway and selectively binds TRAF1. It can induce p38 and JNK MAPK cascades when overexpressed, may play a role in apoptosis, stimulates T-cell proliferation with CD3 signalling, and is involved in dental enamel formation.
RELT stands for RELT TNF receptor. Its UniProt name is tumour necrosis factor receptor superfamily member 19L, and aliases include TNFRSF19L and FLJ14993. Two alternatively spliced transcript variants have been reported, and both encode the same protein.
RELT has a mouse ortholog, Relt, so the receptor can be studied in mouse models. Check the datasheet of any product for its validated reactivity. The source data do not name a rat ortholog.
TNF receptor superfamily members, TRAF adaptors, MAP kinases and immune signalling targets related to RELT.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q969Z4; product specifications from Assay Genie datasheets.