SBSPON
SBSPON (somatomedin B and thrombospondin type 1 domain containing) is a secreted protein located in the extracellular matrix. It is also known as RPESP and by the previous symbol C8orf84, and it belongs to the thrombospondin family. Browse Assay Genie's current range of SBSPON research reagents below, or read on for the biology behind the target.
SBSPON is predicted to be a structural constituent of the extracellular matrix, and the protein is located in the extracellular matrix. UniProt classifies it as a secreted protein found in the extracellular space and matrix. No detailed functional annotation has been curated for it so far, so its precise biochemical role remains to be established experimentally.
The SBSPON gene encodes the somatomedin-B and thrombospondin type-1 domain-containing protein, which UniProt places in the thrombospondin family. The name reflects its domain content: a somatomedin B domain and a thrombospondin type 1 domain. The mouse ortholog is designated Sbspon, which allows comparative studies in mouse models.
The gene was previously named chromosome 8 open reading frame 84 (C8orf84), and the alias RPESP also appears in the literature and databases. Researchers working with this target should check both the current and former symbols when searching publications. Because the protein is a predicted matrix component, it is of interest to those studying extracellular matrix composition and the poorly characterised members of the thrombospondin family.
SBSPON is predicted to be a structural constituent of the extracellular matrix, making it relevant to studies of matrix composition.
As a thrombospondin family member, SBSPON offers a route to explore less characterised proteins carrying thrombospondin type 1 domains.
UniProt lists SBSPON as secreted into the extracellular space, so it is relevant to work on secreted and matrix-associated proteins.
The mouse ortholog Sbspon supports cross-species investigation of this poorly annotated gene and its protein.
SBSPON is predicted to be a structural constituent of the extracellular matrix, and the protein is located in the extracellular matrix. UniProt holds no curated function annotation, so its specific molecular role has not been defined. It is a secreted member of the thrombospondin family.
SBSPON stands for somatomedin B and thrombospondin type 1 domain containing. It is also called RPESP, and its previous symbol was C8orf84, from the earlier name chromosome 8 open reading frame 84. UniProt names the protein somatomedin-B and thrombospondin type-1 domain-containing protein.
A mouse ortholog, Sbspon, is recorded for the human gene, so the gene is conserved at least between human and mouse. No rat ortholog is given in the data supplied. Check the datasheet of any product for its validated reactivity.
Thrombospondin family members and other extracellular matrix proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IVN8; product specifications from Assay Genie datasheets.