EPN1
EPN1 (epsin 1) is a member of the epsin protein family that binds clathrin and membranes enriched in PtdIns(4,5)P2. It modifies membrane curvature and regulates receptor-mediated endocytosis through clathrin-coated vesicles. Browse Assay Genie's current range of EPN1 research reagents below, or read on for the biology behind the target.
EPN1 is an endocytic adaptor that binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). By engaging these membranes it modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. In this way the EPN1 protein helps to regulate receptor-mediated endocytosis, the process by which cells internalise receptors and their bound cargo.
The EPN1 gene encodes a member of the epsin protein family, and the encoded protein, Epsin-1, binds clathrin. This interaction places it in the machinery that drives endocytosis of clathrin-coated vesicles. UniProt records Epsin-1 in the cytoplasm, at the cell membrane and in clathrin-coated pits, as well as in the nucleus. Orthologous genes are present in mouse and rat, both named Epn1, which allows the biology of epsin 1 to be studied in common model systems.
Epsin 1 is also of interest in cancer research. According to the NCBI Gene summary, loss of function of this gene is associated with reduced tumour growth and progression in certain cancer types. Researchers studying endocytic trafficking, membrane remodelling and receptor regulation therefore use EPN1 as a reference point, often alongside other epsin family members such as EPN3.
EPN1 binds clathrin and takes part in the endocytosis of clathrin-coated vesicles, making it a core component for studying vesicle formation.
Epsin-1 binds PtdIns(4,5)P2-rich membranes and modifies curvature, supporting work on how lipids and proteins shape clathrin-coated invaginations.
EPN1 regulates receptor-mediated endocytosis, so it is relevant to research on how cells internalise and control surface receptors.
Loss of EPN1 function is associated with reduced tumour growth and progression in certain cancer types, motivating studies of its role in disease.
EPN1 binds membranes enriched in PtdIns(4,5)P2, modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. It also binds clathrin and regulates receptor-mediated endocytosis, contributing to the endocytosis of clathrin-coated vesicles.
They refer to the same target. EPN1 is the HGNC gene symbol, epsin 1 is the approved gene name, and Epsin-1 is the UniProt protein name. No other aliases or previous symbols are listed. It belongs to the epsin family.
Mouse and rat both have an orthologous gene named Epn1. NCBI Gene reports that loss of function of EPN1 is associated with reduced tumour growth and progression in certain cancer types. Check the datasheet of any product for its validated reactivity.
Other epsin family members and related endocytosis targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6I3; product specifications from Assay Genie datasheets.