GNLY
GNLY (granulysin) is a secreted antimicrobial protein found in the cytotoxic granules of cytotoxic T lymphocytes and natural killer cells. It kills intracellular pathogens and is also known as NKG5, LAG-2, D2S69E and TLA519. Browse Assay Genie's current range of GNLY research reagents below, or read on for the biology behind the target.
GNLY is an antimicrobial protein that kills intracellular pathogens. It is active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi and parasites, and it kills Mycobacterium tuberculosis. This breadth of activity makes granulysin a useful protein for studying how cytotoxic lymphocytes contribute to host defence beyond the killing of infected or abnormal cells.
The GNLY gene product belongs to the saposin-like protein (SAPLIP) family, and HGNC places it in the saposin B type domain containing gene group. The protein is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. It is present in the granules of cytotoxic T lymphocytes and natural killer cells, and UniProt annotates it as a secreted protein. Researchers working with the GNLY gene or granulysin protein therefore often study it alongside granule-mediated cytotoxicity and degranulation.
NCBI Gene reports that alternatively spliced transcript variants encoding different isoforms have been identified. Besides its approved name granulysin, the target appears in the literature under the aliases NKG5, LAG-2, LAG2, D2S69E and TLA519, which is worth remembering when searching for earlier work on this antimicrobial effector.
Granulysin kills a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi and parasites, making it a model effector for studying innate and adaptive host defence.
GNLY has antimicrobial activity against Mycobacterium tuberculosis, so it is studied in work on how immune cells control intracellular pathogens.
Granulysin is stored in the cytotoxic granules of cytotoxic T lymphocytes and natural killer cells and released upon antigen stimulation, linking it to granule-mediated effector function.
As a member of the saposin-like protein family, granulysin is used to explore how saposin-fold proteins act in antimicrobial and cytotoxic roles.
GNLY encodes granulysin, an antimicrobial protein that kills intracellular pathogens. It acts against Gram-positive and Gram-negative bacteria, fungi and parasites, and kills Mycobacterium tuberculosis. It is stored in the cytotoxic granules of cytotoxic T lymphocytes and natural killer cells and released upon antigen stimulation.
GNLY is also known as NKG5, LAG-2, LAG2, D2S69E and TLA519, and its approved name is granulysin. NCBI Gene notes that alternatively spliced transcript variants encoding different isoforms have been identified, so check which form a given reagent recognises.
Granulysin is a member of the saposin-like protein (SAPLIP) family, and HGNC lists it in the saposin B type domain containing group. Mouse and rat orthologues are not specified in the data used here, so check the datasheet of any product for its validated reactivity.
Other cytotoxic granule proteins, effector molecules and immune markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P22749; product specifications from Assay Genie datasheets.