CAP1
CAP1 (cyclase associated actin cytoskeleton regulatory protein 1, also known as CAP or adenylyl cyclase-associated protein 1) is a member of the CAP family that directly regulates actin filament dynamics. It has been implicated in mRNA localisation and the establishment of cell polarity. Browse Assay Genie's current range of CAP1 research reagents below, or read on for the biology behind the target.
CAP1 directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localisation and the establishment of cell polarity. As a regulator of the actin cytoskeleton, it is a useful subject for studies of how cells change shape, organise internal components and respond to polarity cues. UniProt assigns the protein to the cell membrane and places it in the CAP family.
The human CAP1 gene encodes a protein related to the Saccharomyces cerevisiae CAP protein, which is involved in the cyclic AMP pathway. This relationship explains the original name, adenylate cyclase-associated protein 1, and the shorter alias CAP. According to the NCBI Gene summary, the human protein can interact with other molecules of the same protein, as well as with CAP2 and actin. Self-association and partnership with a second CAP family member are therefore central to how CAP1 is understood to work.
Alternatively spliced transcript variants of the CAP1 gene have been identified, and these encode different isoforms. Researchers working with CAP1 should therefore consider which isoform or region of the protein is relevant to their question. The mouse ortholog is designated Cap1, which allows comparison between human and mouse systems. The HGNC full name, cyclase associated actin cytoskeleton regulatory protein 1, reflects both the yeast-derived history and the actin-focused role of the human protein.
CAP1 directly regulates filament dynamics, making it a focus for work on how actin organisation is controlled in cells.
CAP1 has been implicated in establishing cell polarity, a process central to development and cell morphology.
CAP1 has been linked to mRNA localisation, connecting cytoskeletal regulation with the spatial organisation of gene expression.
CAP1 interacts with itself, with CAP2 and with actin, providing a basis for studying CAP family complexes.
CAP1 directly regulates actin filament dynamics. It has also been implicated in complex developmental and morphological processes, including mRNA localisation and the establishment of cell polarity. UniProt lists its subcellular location as the cell membrane, and it belongs to the CAP family of proteins.
CAP1 is also called CAP, adenylyl cyclase-associated protein 1 and adenylate cyclase-associated protein 1 (yeast). The gene has alternatively spliced transcript variants that encode different isoforms, so check which isoform is relevant to your experiment, and check the datasheet of any product for its validated reactivity.
The human CAP1 gene encodes a protein related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. Human CAP1 can interact with itself, with CAP2 and with actin. The mouse ortholog is Cap1, which supports cross-species comparison.
CAP2, the interaction partner of CAP1, along with other CAP-named proteins and related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q01518; product specifications from Assay Genie datasheets.