APRIL
APRIL (TNF superfamily member 13, also known as CD256) is a secreted cytokine of the tumour necrosis factor ligand family. It binds TNFRSF13B/TACI and TNFRSF17/BCMA, and is important for B cell development. Browse Assay Genie's current range of APRIL research reagents below, or read on for the biology behind the target.
APRIL is a cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. It is a ligand for BCMA, a member of the TNF receptor family, and the ligand and its receptor are both important for B cell development. UniProt annotation also assigns APRIL a role in the regulation of tumour cell growth, and suggests it may be involved in monocyte/macrophage-mediated immunological processes.
In vitro experiments suggest that APRIL may be able to induce apoptosis through its interaction with other TNF receptor family proteins, such as TNFRSF6/FAS and TNFRSF14/HVEM. The protein is secreted and belongs to the tumour necrosis factor family. It is encoded by the TNFSF13 gene, a member of the CD molecules and tumour necrosis factor superfamily gene groups, and the mouse ortholog is Tnfsf13. Researchers studying this APRIL gene or its product will find it described under the aliases APRIL and CD256.
Alternative splicing of the gene results in multiple transcript variants. Some transcripts skip the last exon of the upstream gene, TNFSF12, and continue into the second exon of TNFSF13. Such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. The previous HGNC name for the gene was tumour necrosis factor (ligand) superfamily, member 13.
APRIL and its receptor are both important for B cell development, making the ligand a focus for studies of B cell regulation.
APRIL binds TACI and BCMA, providing a model for ligand-receptor interactions within the TNF ligand and receptor families.
UniProt annotation links APRIL to the regulation of tumour cell growth, a basis for cancer biology investigations.
APRIL may induce apoptosis via FAS and HVEM interactions in vitro, and may contribute to monocyte/macrophage-mediated immunological processes.
APRIL is a secreted cytokine that binds TNFRSF13B/TACI and TNFRSF17/BCMA. It is important for B cell development, plays a role in regulating tumour cell growth, and may be involved in monocyte/macrophage-mediated immunological processes.
APRIL is encoded by TNFSF13, short for TNF superfamily member 13, and is also called CD256. UniProt lists it as tumour necrosis factor ligand superfamily member 13. Alternative splicing produces multiple transcript variants, including TNFSF12-TNFSF13 read-through transcripts.
Yes. The mouse ortholog is Tnfsf13. APRIL belongs to the TNF ligand family, and the human protein's interactions with BCMA and TACI are central to its biology. Check the datasheet of any product for its validated reactivity.
Other TNF superfamily ligands that sit alongside APRIL in cytokine and immune signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75888; product specifications from Assay Genie datasheets.