BCL6B
BCL6B (BCL6B transcription repressor, also known as ZBTB28, BAZF and ZNF62) is a nuclear zinc finger protein that acts as a sequence-specific transcriptional repressor. It works in association with BCL6 and may contribute to early B-cell development. Browse Assay Genie's current range of BCL6B research reagents below, or read on for the biology behind the target.
BCL6B is a sequence-specific transcriptional repressor. UniProt annotates it as acting in association with BCL6, and it may function in a narrow stage of, or be related to certain events in, early B-cell development. NCBI Gene summarises its molecular activity as sequence-specific double-stranded DNA binding, and predicts roles in the regulation of gene expression, the regulation of inflammatory response and the type 2 immune response.
The BCL6B gene encodes B-cell CLL/lymphoma 6 member B protein, which is located in the nucleus and is predicted to be active in the nucleoplasm. HGNC classifies it within two groups: C2H2-type zinc fingers and BTB domain-containing proteins. This combination of a DNA-binding zinc finger region and a BTB domain is typical of transcription factors that regulate gene expression. The mouse ortholog is Bcl6b, which allows the biology to be studied in murine models.
The target has accumulated several names. Besides BCL6B, the approved symbol, it has been called ZBTB28, BAZF and ZNF62. Earlier HGNC names include zinc finger protein 62 and B-cell CLL/lymphoma 6, member B (zinc finger protein). Researchers studying BCL6B often work alongside BCL6, its partner in transcriptional repression, when examining transcriptional control in B-cell biology and immune regulation.
BCL6B may act at a narrow stage of, or in events related to, early B-cell development, making it a candidate for lymphocyte differentiation studies.
BCL6B is a sequence-specific DNA-binding repressor that acts together with BCL6, providing a model for BTB zinc finger repressor function.
NCBI Gene predicts that BCL6B is involved in regulating the inflammatory response, pointing to roles in immune signalling and gene control.
BCL6B is predicted to participate in the type 2 immune response, an area where transcriptional regulators shape immune cell programmes.
BCL6B acts as a sequence-specific transcriptional repressor in association with BCL6. It binds double-stranded DNA and is located in the nucleus. UniProt notes that it may function in a narrow stage of, or be related to some events in, early B-cell development.
BCL6B is also known as ZBTB28, BAZF and ZNF62. Its full name is BCL6B transcription repressor, and UniProt lists it as B-cell CLL/lymphoma 6 member B protein. Earlier HGNC names include zinc finger protein 62 and B cell CLL/lymphoma 6B.
A mouse ortholog, Bcl6b, is recorded for the human gene, so murine systems can be used to study its function. The human protein belongs to the BTB domain and C2H2 zinc finger groups. Check the datasheet of any product for its validated reactivity.
BCL6, other BCL-family transcription regulators and related B-cell lymphoma proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N143; product specifications from Assay Genie datasheets.