STOML2
STOML2 (stomatin like 2, also known as SLP-2 or HSPC108) is a mitochondrial member of the stomatin family. It probably regulates mitochondrial biogenesis and activity, binds cardiolipin-enriched membranes and is linked to T-cell activation through the T-cell receptor signalling complex. Browse Assay Genie's current range of STOML2 research reagents below, or read on for the biology behind the target.
STOML2 is a mitochondrial protein that probably regulates the biogenesis and activity of mitochondria. It stimulates cardiolipin biosynthesis and binds cardiolipin-enriched membranes, where it recruits and stabilises proteins including prohibitin. Through this activity it may help organise functional microdomains in mitochondrial membranes. It is also required for mitochondrial hyperfusion, a pro-survival response to stress that increases ATP production by mitochondria.
Through its control of mitochondrial function, STOML2 may contribute to several processes, including cell migration, cell proliferation, T-cell activation, calcium homeostasis and the cellular response to stress. It may support calcium homeostasis by negatively regulating calcium efflux from mitochondria. The protein may also help organise functional domains at the plasma membrane, and it has been linked to T-cell activation through association with the T-cell receptor signalling complex and its regulation. NCBI Gene annotation lists GTPase binding, T cell receptor binding and cardiolipin binding activities, and places the protein at the immunological synapse, membrane rafts and the mitochondrial envelope.
UniProt records STOML2 in the cell membrane, mitochondrion inner membrane, mitochondrial intermembrane space, membrane rafts and the cytoskeleton. It belongs to the band 7/mec-2 family and to the HGNC stomatin family. The gene was previously named stomatin (EPB72)-like 2, and the protein is also called SLP-2 and HSPC108. Researchers studying the STOML2 gene or protein will find orthologues named Stoml2 in both mouse and rat.
STOML2 probably regulates mitochondrial biogenesis and activity, and stimulates cardiolipin biosynthesis.
STOML2 is required for mitochondrial hyperfusion, a pro-survival response to stress that increases mitochondrial ATP production.
STOML2 associates with the T-cell receptor signalling complex and may regulate T-cell activation at the immunological synapse.
STOML2 may negatively regulate calcium efflux from mitochondria, contributing to intracellular calcium ion homeostasis.
STOML2 is a mitochondrial protein that probably regulates mitochondrial biogenesis and activity. It stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes and recruits and stabilises proteins such as prohibitin. It is also required for mitochondrial hyperfusion, a pro-survival response to cellular stress.
STOML2 is also known as SLP-2 and HSPC108. Its full HGNC name is stomatin like 2, and it was previously called stomatin (EPB72)-like 2. UniProt lists the protein as stomatin-like protein 2, mitochondrial.
Yes. Mouse and rat both have an orthologous gene named Stoml2. The protein belongs to the band 7/mec-2 family, and HGNC places the human gene in the stomatin family. Check the datasheet of any product for its validated reactivity.
Other stomatin family members, mitochondrial membrane proteins and T-cell signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJZ1; product specifications from Assay Genie datasheets.