RGMA
RGMA (repulsive guidance molecule BMP co-receptor a, also known as RGM) is a membrane-anchored glycoprotein of the repulsive guidance molecule family. It guides axons in the developing and adult nervous system and acts as a bone morphogenetic protein (BMP) co-receptor. Browse Assay Genie's current range of RGMA research reagents below, or read on for the biology behind the target.
RGMA performs several functions in the developing and adult nervous system. It regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and influences the formation of mature synapses. It does this largely by binding its receptor NEO1 (neogenin). This binding activates the RHOA-ROCK1 (Rho-kinase) signalling pathway through a UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade. The result is collapse of the neuronal growth cone and inhibition of neurite outgrowth. Binding of RGMA to neogenin also leads to HRAS inactivation, through the HRAS-PTK2/FAK1-AKT1 pathway.
RGMA also functions as a BMP co-receptor that may signal through SMAD1, SMAD5 and SMAD8. This links a neuronal guidance molecule to the BMP signalling pathway. The RGMA gene encodes a glycosylphosphatidylinositol-anchored glycoprotein that sits on the cell membrane. It is described as an axon guidance protein in the central nervous system, both during development and in adulthood. Alternate splicing of the gene gives multiple transcript variants. The mouse ortholog is Rgma, which makes it possible to study the protein in rodent models.
The HGNC gene group for RGMA is the repulsive guidance molecule family. The previous names are RGM domain family, member A, and repulsive guidance molecule family member a. NCBI Gene notes that RGMA may also act as a tumour suppressor in some cancers. This gives the protein relevance beyond neuroscience. Researchers studying RGMA often work on neurite outgrowth, growth cone dynamics, neogenin signalling and BMP-SMAD pathways, using the RGMA protein, RGMA antibody and RGMA ELISA kit formats suited to their question.
RGMA is an axon guidance protein of the developing and adult central nervous system that inhibits neurite outgrowth.
RGMA regulates cephalic neural tube closure, making it a focus in studies of early nervous system development.
RGMA binding to NEO1 activates RHOA-ROCK1 signalling and collapses the neuronal growth cone, and it also inactivates HRAS.
RGMA acts as a BMP co-receptor that may signal through SMAD1, SMAD5 and SMAD8, and may suppress tumours in some cancers.
RGMA is a membrane-anchored guidance protein in the nervous system. It binds neogenin (NEO1) to activate RHOA-ROCK1 signalling, collapsing the growth cone and inhibiting neurite outgrowth. It also regulates neural tube closure and acts as a BMP co-receptor that may signal through SMAD1, SMAD5 and SMAD8.
RGMA is also known as RGM. Earlier names include RGM domain family, member A, and repulsive guidance molecule family member a. The current HGNC name is repulsive guidance molecule BMP co-receptor a. NCBI Gene reports that alternate splicing gives multiple transcript variants.
NCBI Gene reports that RGMA may function as a tumour suppressor in some cancers. The mouse ortholog is Rgma. Check the datasheet of any product for its validated reactivity before using it with a given species.
Receptors, signalling partners and BMP pathway proteins connected to RGMA function in axon guidance.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96B86; product specifications from Assay Genie datasheets.