TCL1A
TCL1A (TCL1 family AKT coactivator A, also known as TCL1 or T-cell leukaemia/lymphoma protein 1A) is a small cytoplasmic and nuclear protein that enhances activation of the cell survival kinase AKT. Its overexpression is linked to mature T cell leukaemia. Browse Assay Genie's current range of TCL1A research reagents below, or read on for the biology behind the target.
TCL1A acts as a coactivator of the cell survival kinase AKT. It enhances the phosphorylation and activation of AKT1, AKT2 and AKT3, and promotes the nuclear translocation of AKT1. Through this activity, the TCL1A protein enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival.
The protein belongs to the TCL1 family. According to UniProt, it is found in the cytoplasm, nucleus, microsome and endoplasmic reticulum. The human TCL1A gene is the source of the protein, and a mouse ortholog, Tcl1a, is recorded in the gene data. In normal T cells, TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation.
TCL1A takes its name from its role in T cell leukaemia and lymphoma; the previous symbol was TCL1 and the previous name was T cell leukaemia/lymphoma 1A. Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukaemia. In these cases, chromosomal rearrangements bring the gene close to the regulatory elements of the T-cell antigen receptor (TCR) alpha or beta loci. This combination of AKT coactivation and disease association makes TCL1A a useful subject for studies of survival signalling and lymphoid malignancy.
TCL1A enhances phosphorylation and activation of AKT1, AKT2 and AKT3, making it a point of study for how AKT activity is regulated.
Overexpression of TCL1 after chromosomal rearrangements near TCR loci has been implicated in the development of mature T cell leukaemia.
TCL1 is expressed in CD4-/CD8- T cells but not at later stages of differentiation, which supports work on developmental regulation.
TCL1A enhances proliferation, stabilises mitochondrial membrane potential and promotes cell survival, relevant to studies of apoptosis resistance.
TCL1A is a coactivator of the survival kinase AKT. It enhances the phosphorylation and activation of AKT1, AKT2 and AKT3 and promotes nuclear translocation of AKT1. As a result, it enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival.
Yes. TCL1 is the previous symbol for the gene now named TCL1A by HGNC, and the previous name was T cell leukaemia/lymphoma 1A. UniProt lists the protein as T-cell leukaemia/lymphoma protein 1A. Literature and databases may use any of these names, so search with all of them.
Overexpression of the TCL1 gene has been implicated in mature T cell leukaemia, where chromosomal rearrangements place the gene near TCR-alpha or TCR-beta regulatory elements. In normal T cells it is expressed in CD4-/CD8- cells but not at later differentiation stages. Mouse Tcl1a is the recorded ortholog.
Other AKT isoforms, TCL1 family members and T cell markers relevant to survival signalling and lymphoid research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P56279; product specifications from Assay Genie datasheets.