STARD10 is a phospholipid transfer protein. It is able to transfer phosphatidylcholine (PC) and phosphatidylethanolamine (PE) between membranes. It shows a preference for lipid species that carry a palmitoyl or stearoyl chain at the sn-1 position and an unsaturated fatty acyl chain (18:1 or 18:2) at the sn-2 position. UniProt also notes that the protein may play metabolic roles in sperm maturation or fertilization.

The STARD10 gene belongs to the HGNC group of StAR related lipid transfer domain containing genes, which encode proteins built around a START lipid-binding domain. UniProt records localisation to the cytoplasm, to membranes and to the cilium or flagellum, and NCBI Gene reports it as located in the cytosol. NCBI Gene predicts that STARD10 enables lipid carrier activity and phosphatidylcholine binding, and that it is involved in the phosphatidylcholine biosynthetic process. It is also predicted to act upstream of or within bile acid secretion and positive regulation of the peroxisome proliferator activated receptor signalling pathway.

The protein has gone by several names. Earlier HGNC names include serologically defined colon cancer antigen 28 and START domain containing 10, which account for the aliases SDCCAG28 and NY-CO-28. CGI-52 and PCTP2 are further aliases. The mouse ortholog is Stard10. Researchers studying the STARD10 gene or STARD10 protein generally do so in the context of intracellular lipid transport and phospholipid metabolism.