ETS1
ETS1 (ETS proto-oncogene 1, transcription factor), also known as ETS-1, EWSR2 and FLJ10768, is a member of the ETS family of transcription factors. It binds DNA through a conserved ETS domain and regulates genes involved in stem cell development, cell senescence and death, and tumorigenesis. Browse Assay Genie's current range of ETS1 research reagents below, or read on for the biology behind the target.
ETS1 is a transcription factor defined by a conserved ETS DNA-binding domain, which recognises the core consensus sequence GGAA/T in target genes. Depending on the gene and context, ETS family proteins act either as transcriptional activators or as repressors, and they control the expression of numerous genes. The ETS1 protein is annotated in UniProt as localising to the nucleus and the cytoplasm.
The ETS1 gene encodes Protein C-ets-1 and belongs to the ETS transcription factor family. Alternatively spliced transcript variants encoding different isoforms have been described. One annotated isoform relationship is that the protein acts as a dominant-negative for isoform c-ETS-1A, so isoform composition is worth considering when designing experiments or interpreting results. Mouse and rat each have an orthologous Ets1 gene.
According to the NCBI Gene summary, ETS family proteins including ETS1 are involved in stem cell development, cell senescence and death, and tumorigenesis. The gene was previously named v-ets avian erythroblastosis virus E26 oncogene homolog 1, which reflects its origin as the cellular counterpart of a viral oncogene. Researchers studying ETS1 often work alongside related family members such as ETS2, and use an ETS1 antibody or ETS1 ELISA kit to examine expression and regulation in their model systems.
ETS1 recognises the GGAA/T core motif and can activate or repress numerous target genes, making it a model for ETS-domain DNA binding.
ETS family transcription factors, including ETS1, are involved in stem cell development, so ETS1 is studied in differentiation and lineage programmes.
ETS1 is implicated in cell senescence and cell death, relevant to work on proliferative arrest and survival pathways.
As a proto-oncogene product, ETS1 is investigated for its involvement in tumorigenesis and in how ETS factors shape gene expression in cancer.
ETS1 is a transcription factor that binds the core DNA sequence GGAA/T through its conserved ETS domain. It can act as an activator or repressor of numerous genes and is involved in stem cell development, cell senescence and death, and tumorigenesis.
ETS1 is also called ETS-1, EWSR2 and FLJ10768, and was formerly named v-ets avian erythroblastosis virus E26 oncogene homolog 1. Alternatively spliced variants encode different isoforms, and UniProt notes a dominant-negative action on isoform c-ETS-1A.
Yes. Mouse and rat both have an orthologous gene named Ets1, so the human ETS1 protein can be studied in common rodent models. Please check the datasheet of any product for its validated reactivity.
Other ETS family transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P14921; product specifications from Assay Genie datasheets.