RASSF2
RASSF2 (Ras association domain family member 2, also known as KIAA0168 and CENP-34) is a Ras association domain-containing protein that acts as a potential tumour suppressor. It functions as a KRAS-specific effector and may promote apoptosis and cell cycle arrest. Browse Assay Genie's current range of RASSF2 research reagents below, or read on for the biology behind the target.
RASSF2 is a potential tumour suppressor that acts as a KRAS-specific effector protein. Effectors of this kind link active Ras proteins to downstream cellular responses, and RASSF2 is reported to promote apoptosis and cell cycle arrest. It also stabilises STK3/MST2 by protecting the kinase from proteasomal degradation, which ties RASSF2 to the regulation of STK3 protein levels.
The RASSF2 gene encodes a protein that contains a Ras association domain, the feature that defines the Ras association domain family in HGNC. According to the NCBI Gene summary, two alternatively spliced transcripts have been reported, and both encode the same isoform. Researchers working with the RASSF2 protein will therefore be dealing with a single reported isoform. UniProt records the protein in the nucleus, the cytoplasm and at the kinetochore of the centromere on chromosomes. Rodent orthologs are designated Rassf2 in both mouse and rat.
The gene has carried several names. Earlier HGNC naming was Ras association (RalGDS/AF-6) domain family member 2, and the aliases KIAA0168 and CENP-34 are still in use. The NCBI summary notes that, as in its cattle and sheep counterparts, the RASSF2 gene is located near the prion gene. Because RASSF2 is a candidate tumour suppressor and a KRAS-specific effector, it is of interest in studies of Ras signalling, apoptosis and cell cycle control, alongside other members of the RASSF family such as RASSF1.
RASSF2 is described as a potential tumour suppressor, making it a candidate for studies of growth control and cancer biology.
As a KRAS-specific effector protein, RASSF2 is relevant to work on how Ras signals are relayed to downstream partners.
RASSF2 may promote apoptosis and cell cycle arrest, so it is studied in pathways that govern cell survival and proliferation.
RASSF2 protects STK3/MST2 from proteasomal degradation, offering a route into studies of kinase stabilisation and protein turnover.
RASSF2 is a potential tumour suppressor that acts as a KRAS-specific effector protein. It may promote apoptosis and cell cycle arrest, and it stabilises STK3/MST2 by protecting it from proteasomal degradation. UniProt places it in the nucleus, cytoplasm and kinetochore.
RASSF2 is also known as KIAA0168 and CENP-34. Its earlier HGNC name was Ras association (RalGDS/AF-6) domain family member 2. UniProt lists the protein as Ras association domain-containing protein 2. NCBI reports two splice transcripts that encode the same isoform.
Mouse and rat both have a Rassf2 ortholog. The NCBI Gene summary also notes that, as in cattle and sheep, the gene lies near the prion gene. Check the datasheet of any product for its validated reactivity.
Other members of the Ras association domain family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50749; product specifications from Assay Genie datasheets.