TRPV3
TRPV3 (transient receptor potential cation channel subfamily V member 3, also known as VRL3) is a non-selective, calcium-permeant cation channel activated by warm temperatures. It belongs to the TRPV subfamily of ankyrin repeat-containing channels and acts in temperature sensation and in the regulation of hair growth. Browse Assay Genie's current range of TRPV3 research reagents below, or read on for the biology behind the target.
TRPV3 is a non-selective cation channel with permeability to calcium. It is activated by innocuous warm temperatures and shows an increased response at noxious temperatures above 39 degrees Celsius; NCBI describes activation across a range of roughly 22 to 40 degrees C. Activation shows outward rectification, and the channel pore can dilate to allow passage of larger cations. TRPV3 may associate with TRPV1 and may modulate its activity.
The TRPV3 protein belongs to the transient receptor family (TC 1.A.4), TrpV subfamily, and sits in the HGNC groups for ankyrin repeat domain containing proteins and TRPV channels. Thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and each is activated at distinct physiological temperatures. UniProt lists the protein at the cell membrane, in the cytoplasm and at the lysosome. The TRPV3 gene lies close to another family member gene on chromosome 17, and the two encoded proteins are thought to associate to form heteromeric channels. Multiple transcript variants encoding different isoforms have been reported. The mouse ortholog is Trpv3.
Beyond thermosensation, TRPV3 is a negative regulator of hair growth and cycling. TRPV3-coupled signalling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). The family as a whole is also linked to processes such as vasoregulation. Earlier nomenclature named the gene product as VRL3, and the HGNC name uses the form transient receptor potential cation channel subfamily V member 3.
TRPV3 is activated by warm temperatures and is expressed in sensory neurons that terminate in the skin, making it a model for temperature sensing.
TRPV3-coupled signalling suppresses keratinocyte proliferation and drives apoptosis and early catagen, so it is studied in hair growth and cycling.
Outward rectification and a pore that dilates to pass larger cations make TRPV3 a useful subject for studying cation channel gating and permeation.
TRPV3 may associate with TRPV1 and with a neighbouring family member, so it is relevant to studies of heteromeric channel assembly and modulation.
TRPV3 is a non-selective, calcium-permeant cation channel activated by warm temperatures, with a stronger response above 39 degrees Celsius. It contributes to temperature sensation in skin-innervating sensory neurons and negatively regulates hair growth by suppressing keratinocyte proliferation and promoting catagen.
TRPV3 has the alias VRL3, and the older HGNC name used a comma-separated form of the same title. NCBI reports multiple transcript variants encoding different isoforms of the TRPV3 gene product. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Trpv3, is recorded. TRPV3 belongs to the TRPV subfamily, may associate with TRPV1 and may modulate its activity. Its gene lies near another family member on chromosome 17, and the two proteins are thought to form heteromeric channels.
Other TRPV subfamily channels and thermosensitive cation channels studied alongside TRPV3.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NET8; product specifications from Assay Genie datasheets.