DPYSL2
DPYSL2 (dihydropyrimidinase like 2), also known as CRMP2, DRP-2, DRP2 and DHPRP2, is a member of the collapsin response mediator protein family. It contributes to neuronal development and polarity, axon growth and guidance, and semaphorin-driven cytoskeletal remodelling. Browse Assay Genie's current range of DPYSL2 research reagents below, or read on for the biology behind the target.
DPYSL2 plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. It is necessary for signalling by class 3 semaphorins and the subsequent remodelling of the cytoskeleton, and it is required for Sema3A-mediated growth cone collapse. The protein promotes microtubule assembly, and it may also play a role in endocytosis. It has a further role in synaptic signalling through interactions with calcium channels.
The DPYSL2 gene encodes a member of the collapsin response mediator protein (CRMP) family. These proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. UniProt places the protein in the hydantoinase/dihydropyrimidinase family of the metallo-dependent hydrolases superfamily, and HGNC lists it within the M38 metallopeptidases and spectrin repeat containing gene groups. Subcellular locations include the cytosol, the cytoskeleton and membranes. Alternatively spliced transcript variants encoding multiple isoforms have been observed. Orthologues are named Dpysl2 in both mouse and rat.
The name reflects its sequence similarity to dihydropyrimidinase, and the previous name was dihydropyrimidinase-like 2. The gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. For this reason, DPYSL2 is a frequent subject in studies of neuronal wiring, cytoskeletal regulation and neurodegeneration. Researchers working on the DPYSL2 gene often study it alongside its relatives DPYSL3 and DPYSL4.
DPYSL2 contributes to axon growth and guidance, making it a key protein for studying how neurons find their targets.
The protein is necessary for class 3 semaphorin signalling and Sema3A-mediated growth cone collapse, linking guidance cues to cytoskeletal remodelling.
Hyperphosphorylation of DPYSL2 may play a key role in Alzheimer's disease, and the gene is implicated in other neurological disorders.
DPYSL2 promotes microtubule assembly and forms tetramers, supporting work on neuronal polarity and cytoskeletal organisation.
DPYSL2 plays a role in neuronal development and polarity, axon growth and guidance, growth cone collapse and cell migration. It is necessary for class 3 semaphorin signalling and cytoskeletal remodelling, promotes microtubule assembly, and may play a role in endocytosis.
DPYSL2 is also called CRMP2, DRP-2, DRP2 and DHPRP2. Its previous name was dihydropyrimidinase-like 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed, so literature may refer to different forms of the protein.
The DPYSL2 gene has been implicated in multiple neurological disorders. Hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Mouse and rat each carry a Dpysl2 orthologue; check the datasheet of any product for its validated reactivity.
Other dihydropyrimidinase-like family members involved in neuronal guidance, growth and polarity.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16555; product specifications from Assay Genie datasheets.