PACRG
PACRG (parkin coregulated, also known as PARK2CRG, Glup, BUG21 and pf12) is a microtubule inner protein of motile cilia and flagella that also suppresses unfolded-protein toxicity in cells. Its gene sits head-to-head with the parkin gene and shares a bi-directional promoter with it. Browse Assay Genie's current range of PACRG research reagents below, or read on for the biology behind the target.
PACRG is a microtubule inner protein (MIP) that forms part of the dynein-decorated doublet microtubules (DMTs) of the cilia axoneme, a structure required for motile cilia beating. UniProt places the protein in the axoneme of both cilia and flagella. In a separate role, PACRG suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R), a substrate of parkin. When the proteasome is inhibited, it helps form inclusions that contain Pael-R, molecular chaperones, protein degradation molecules and PACRG itself.
The official gene name is parkin coregulated, and the HGNC gene group is armadillo like helical domain containing. Earlier names include PARK2CRG and PARK2 coregulated, and aliases include FLJ32724, Glup, HAK005771, BUG21 and pf12. The PACRG gene is conserved across metazoans, and the mouse ortholog is Pacrg. In vertebrates it is linked head-to-head with the adjacent parkin gene, and the two genes are co-regulated in various tissues through a shared bi-directional promoter. Multiple transcript variants encoding different isoforms have been reported.
The link to parkin gives PACRG its relevance to Parkinson's disease research. Parkin is associated with autosomal recessive juvenile Parkinson's disease, and both genes are associated with susceptibility to leprosy. The PACRG protein forms a large complex with chaperones, including heat shock proteins 70 and 90 and chaperonin components. It is also a component of Lewy bodies in Parkinson's disease patients, and it may protect dopaminergic neurons against the disease.
PACRG is a microtubule inner protein of dynein-decorated doublet microtubules, which makes it relevant to studies of the axoneme and of motile cilia beating.
PACRG is a component of Lewy bodies and may help protect dopaminergic neurons, so it is studied alongside parkin in Parkinson's disease models.
PACRG suppresses unfolded Pael-R-induced cell death and promotes inclusion formation with chaperones when the proteasome is inhibited.
The PACRG and parkin genes are both associated with susceptibility to leprosy, which supports genetic and immunological studies of host response.
PACRG is a microtubule inner protein of the dynein-decorated doublet microtubules in the cilia axoneme, which are required for motile cilia beating. It also suppresses cell death caused by unfolded Pael receptor and helps form chaperone-containing inclusions when the proteasome is inhibited.
PACRG stands for parkin coregulated, previously named PARK2 coregulated. Aliases include PARK2CRG, FLJ32724, Glup, HAK005771, BUG21 and pf12. UniProt lists the protein as parkin coregulated gene protein, and multiple transcript variants encoding different isoforms have been described.
The PACRG gene lies head-to-head with the parkin gene and shares a bi-directional promoter with it. The protein is a component of Lewy bodies in Parkinson's disease patients. It is conserved across metazoans, with a mouse ortholog named Pacrg; check the datasheet of any product for its validated reactivity.
Parkin, chaperone, Pael receptor and other Parkinson's disease and cilia-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96M98; product specifications from Assay Genie datasheets.