MRE11
MRE11 (MRE11 double strand break repair nuclease, also known as MRE11A and ATLD) is a nuclear protein involved in homologous recombination, telomere length maintenance and DNA double-strand break repair. It has intrinsic 3' to 5' exonuclease and endonuclease activity. Browse Assay Genie's current range of MRE11 research reagents below, or read on for the biology behind the target.
MRE11 is a nuclease that acts in the repair of DNA double-strand breaks. On its own, the protein has 3' to 5' exonuclease activity and endonuclease activity. It contains two DNA-binding domains, which allow it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA).
MRE11 forms a complex with the RAD50 homolog. This complex is required for nonhomologous joining of DNA ends and shows increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, MRE11 promotes the joining of noncomplementary ends in vitro, using short homologies near the ends of the DNA fragments. HGNC lists the gene within the MRN complex and BRCA1 C complex groups. Beyond double-strand break repair, the protein is involved in homologous recombination and telomere length maintenance, and UniProt records its localisation to the nucleus, chromosomes and telomeres.
The MRE11 gene belongs to the MRE11/RAD32 family. It has a pseudogene on chromosome 3, and alternative splicing produces two transcript variants that encode different isoforms. The gene has appeared in the literature as MRE11A, and earlier names refer to the yeast meiotic recombination 11 homologue. ATLD is also listed as an alias. Mouse and rat each have an orthologous Mre11 gene, which supports comparative work on this repair factor.
MRE11 contributes to double-strand break repair, making it a central protein for studying how cells detect and process broken DNA ends.
MRE11 is involved in homologous recombination, so it is relevant to studies of recombination-based repair and the nuclease activities that support it.
MRE11 is implicated in telomere length maintenance and localises to telomeres, linking it to research on chromosome end biology.
MRE11 partners with RAD50 in a complex that joins DNA ends, supporting work on nonhomologous end joining and complex function.
MRE11 is a nuclear nuclease involved in homologous recombination, telomere length maintenance and DNA double-strand break repair. It has 3' to 5' exonuclease and endonuclease activity, and it binds both ssDNA and dsDNA through two DNA-binding domains. With RAD50 it forms a complex needed for nonhomologous end joining.
MRE11 is also called MRE11A and ATLD. Earlier names include MRE11 homolog A, double strand break repair nuclease, and MRE11 meiotic recombination 11 homolog A (S. cerevisiae). Alternative splicing of the gene gives two transcript variants that encode different isoforms.
Yes. Mouse and rat both have an ortholog named Mre11, and the protein belongs to the MRE11/RAD32 family. Check the datasheet of any product for its validated reactivity.
Other DNA repair factors, MRN complex components and recombination proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49959; product specifications from Assay Genie datasheets.