RTN1
RTN1 (reticulon 1, also known as NSP or neuroendocrine-specific protein) is a member of the reticulon family of endoplasmic reticulum-associated proteins. It is linked to neuroendocrine secretion and membrane trafficking, and inhibits amyloid precursor protein processing. Browse Assay Genie's current range of RTN1 research reagents below, or read on for the biology behind the target.
RTN1 is a reticulon, a group of proteins associated with the endoplasmic reticulum. Reticulons are involved in neuroendocrine secretion and in membrane trafficking in neuroendocrine cells. The annotated function of RTN1 is to inhibit amyloid precursor protein processing, probably by blocking the activity of BACE1.
Reticulon-1 is found in the endoplasmic reticulum membrane and the Golgi apparatus membrane. The RTN1 gene belongs to the reticulon-encoding gene family, and alternative splicing results in multiple transcript variants. HGNC places it in the reticulons group and also in the group of microRNA protein coding host genes. Mouse and rat both have an orthologous Rtn1 gene, which allows the protein to be studied in common model systems.
The protein was originally named neuroendocrine-specific protein, which gives the alias NSP. RefSeq describes the RTN1 gene as a specific marker for neurological diseases and cancer, and as a potential molecular target for therapy. This makes RTN1 an RTN1 protein of interest for researchers working on neurobiology, amyloid precursor protein processing and endoplasmic reticulum biology. Related family members, including RTN3 and RTN4, are often studied alongside it.
RTN1 inhibits amyloid precursor protein processing, probably by blocking BACE1 activity, so it is relevant to studies of this proteolytic pathway.
The RTN1 gene is considered a specific marker for neurological diseases, making it a candidate for studies of disease mechanisms.
RefSeq describes RTN1 as a marker for cancer and a potential molecular target for therapy, supporting its study in oncology.
Reticulons are involved in neuroendocrine secretion and membrane trafficking, and RTN1 is used to study these ER-linked processes.
RTN1 is an endoplasmic reticulum-associated reticulon. UniProt annotates it as an inhibitor of amyloid precursor protein processing, probably by blocking BACE1 activity. Reticulons more broadly are involved in neuroendocrine secretion and membrane trafficking in neuroendocrine cells.
RTN1 stands for reticulon 1. Its alias is NSP, from the previous name neuroendocrine-specific protein. Alternative splicing of the RTN1 gene results in multiple transcript variants, so researchers should check which variant a reagent is expected to recognise.
RefSeq considers RTN1 a specific marker for neurological diseases and cancer, and a potential molecular target for therapy. Mouse and rat each have an Rtn1 ortholog. Check the datasheet of any product for its validated reactivity.
Other reticulon family members and reticulon 4 receptor proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16799; product specifications from Assay Genie datasheets.