GFOD2
GFOD2 (Gfo/Idh/MocA-like oxidoreductase domain containing 2) is a secreted protein of the Gfo/Idh/MocA family that promotes matrix assembly. It is also known as glucose-fructose oxidoreductase domain-containing protein 2, with the aliases FLJ23802 and MGC11335. Browse Assay Genie's current range of GFOD2 research reagents below, or read on for the biology behind the target.
GFOD2 is annotated in UniProt as a protein that promotes matrix assembly. It is found in the extracellular space and extracellular matrix, which fits with its role in organising the matrix. The NCBI Gene summary, which is based on predictions from the Alliance of Genome Resources, describes GFOD2 as likely to be involved in extracellular matrix organisation and to be active in the extracellular matrix. The molecular mechanism by which GFOD2 promotes assembly is not described in the sources used here.
The GFOD2 protein belongs to the Gfo/Idh/MocA family. The NCBI Gene summary predicts that it enables nucleotide binding activity and oxidoreductase activity. HGNC places the GFOD2 gene in the group of Gfo/Idh/MocA-like oxidoreductase domain containing genes, which is itself part of the wider oxidoreductases group. The UniProt entry lists an EC number of 1.-.-.-, which means that the oxidoreductase class is assigned but the specific reaction is not defined. The mouse ortholog is Gfod2.
The official gene name, Gfo/Idh/MocA-like oxidoreductase domain containing 2, replaced the earlier name glucose-fructose oxidoreductase domain containing 2. The aliases FLJ23802 and MGC11335 are previous identifiers that may turn up in older literature and database records. Researchers studying extracellular matrix biology, or oxidoreductase domain proteins that act outside the cell, may find GFOD2 a useful target to investigate, whether by GFOD2 antibody or GFOD2 ELISA kit approaches.
GFOD2 is annotated as promoting matrix assembly, making it a candidate for studies of how the extracellular matrix is organised.
GFOD2 is localised to the extracellular space and matrix, so it is relevant to work on secreted and matrix-associated proteins.
As a member of the Gfo/Idh/MocA family, GFOD2 is predicted to have nucleotide binding and oxidoreductase activity.
The mouse ortholog Gfod2 and older aliases such as FLJ23802 and MGC11335 help link GFOD2 findings across species and datasets.
UniProt annotates GFOD2 as promoting matrix assembly. The NCBI Gene summary adds predictions that it is involved in extracellular matrix organisation and is active in the extracellular matrix. It is also predicted to have nucleotide binding and oxidoreductase activity.
GFOD2 stands for Gfo/Idh/MocA-like oxidoreductase domain containing 2. UniProt calls it glucose-fructose oxidoreductase domain-containing protein 2. Aliases and previous symbols include FLJ23802 and MGC11335, and the earlier gene name was glucose-fructose oxidoreductase domain containing 2.
A mouse ortholog, Gfod2, is recorded for the human gene. The protein belongs to the Gfo/Idh/MocA family, which is defined by a shared oxidoreductase-like domain. Check the datasheet of any product for its validated reactivity.
Other oxidoreductase domain proteins and extracellular matrix targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q3B7J2; product specifications from Assay Genie datasheets.