MT-ND1
MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1, also known as ND1, NAD1 or MTND1) is a core subunit of mitochondrial respiratory chain complex I. It supports electron transfer from NADH to ubiquinone and is essential for complex I assembly. Browse Assay Genie's current range of MT-ND1 research reagents below, or read on for the biology behind the target.
MT-ND1 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, known as complex I. Complex I catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as the electron acceptor. The MT-ND1 protein is essential for both the catalytic activity and the assembly of the complex. It enables NADH dehydrogenase (ubiquinone) activity and is involved in mitochondrial electron transport from NADH to ubiquinone, as well as in assembly of respiratory chain complex I.
The MT-ND1 gene lies on the mitochondrial genome rather than in the nucleus, and it belongs to the HGNC group of mitochondrially encoded protein coding genes and to the NADH:ubiquinone oxidoreductase core subunits. The protein is a member of the complex I subunit 1 family and is located in the mitochondrial inner membrane, where it forms part of respiratory chain complex I. Researchers working with the MT-ND1 protein often study it as a readout of complex I composition and mitochondrial function. Mouse and rat orthologs are designated Mtnd1 and Mt-nd1.
The gene has previously been called NADH dehydrogenase 1 and mitochondrially encoded NADH dehydrogenase 1, and the symbols ND1, NAD1 and MTND1 appear in older literature. MT-ND1 has been implicated in several diseases, including MELAS syndrome, multiple neurodegenerative diseases, multiple optic nerve diseases, toxic shock syndrome and type 2 diabetes mellitus. It has also been described as a biomarker of Alzheimer's disease, Parkinson's disease and multiple sclerosis.
MT-ND1 is a core complex I subunit that supports electron transfer from NADH to ubiquinone in the respiratory chain.
The protein is essential for the catalytic activity and assembly of complex I, making it a useful subject for assembly research.
MT-ND1 is implicated in multiple neurodegenerative diseases and described as a biomarker of Alzheimer's disease, Parkinson's disease and multiple sclerosis.
MT-ND1 is implicated in MELAS syndrome, optic nerve disease and type 2 diabetes mellitus, linking complex I function to disease.
MT-ND1 is a core subunit of mitochondrial respiratory chain complex I. Complex I catalyses electron transfer from NADH through the respiratory chain, with ubiquinone as the electron acceptor. MT-ND1 is essential for the catalytic activity and assembly of the complex and sits in the mitochondrial inner membrane.
The gene is also listed as ND1, NAD1 and MTND1. Earlier names include NADH dehydrogenase 1 and mitochondrially encoded NADH dehydrogenase 1. UniProt names the protein NADH-ubiquinone oxidoreductase chain 1, and it belongs to the complex I subunit 1 family.
MT-ND1 is implicated in MELAS syndrome, neurodegenerative and optic nerve diseases, toxic shock syndrome and type 2 diabetes mellitus. Orthologs exist in mouse (Mtnd1) and rat (Mt-nd1); check the datasheet of any product for its validated reactivity.
Other mitochondrially encoded respiratory chain and ATP synthase subunits with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P03886; product specifications from Assay Genie datasheets.